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タイトル: Adverse effects of tributyltin on reproduction of Japanese medaka, Oryzias latipes
著者: NAKAYAMA, Kei
OSHIMA, Yuji
キーワード: tributyltin
Japanese medaka
reproductive toxicity
behaviors
mixture toxicity
発行日: 2008年8月20日
出版者: International Coastal Research Center, Ocean Research Institute, the University of Tokyo
掲載誌情報: Coastal marine science. Vol.32 No.1, 2008.8, pp. 1-8
抄録: Tributyltin (TBT) is a typical endocrine disruptor that can induce imposex in mollusks and interfere with the reproduction in bivalves and fish. Our group has been studied the toxic effects of TBT using Japanese medaka (Oryzias latipes) as a model organism, and evaluated the effects on reproduction and behavior of medaka exposed to TBT. A series of our studies has demonstrated that TBT suppresses mating behavior in male and depresses fertility. We also observed that TBT exposure causes abnormalities in embryonic development, such as eye deformity, decreased hatchability and swim-up failure, but does not affect sexual development in the progenies from TBT-exposed fish. Furthermore, TBT alters not only the mating behavior but also other general, non-sexual, behaviors. Since behavioral abnormalities may influence individual survivability or populational structure, we believe that it is necessary to evaluate the effects of environmental pollutants on animal behaviors. In addition, the developmental toxicity of TBT was enhanced by co-exposure to PCBs, even when their exposure levels were below the no-observed-effect concentrations of the individual chemicals. Mixture toxicity of environmental contaminants is an emerging issue. It is quite important to emphasize and evaluate mixture toxicities of contaminants at environmentally relevant levels.
URI: http://hdl.handle.net/2261/20990
ISSN: 13493000
出現カテゴリ:Coastal Marine Science
Coastal Marine Science

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