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タイトル: Functional and anatomical organization of forward projection from area TE to perirhinal neurons representing visual long-term memory in monkeys
その他のタイトル: 大脳側頭葉長期記憶ニューロンへの神経投射の放散度 : 生理学的解剖学的手法による定量的解析
著者: Yoshida, Masatoshi
著者(別言語): 吉田, 正俊
発行日: 2003年6月18日
抄録: A number of studies have shown that the perirhinal (PRh) cortex, which is part of the medial temporal lobe memory system, plays an important role in declarative long-term memory. The PRh cortex contains neurons that represent visual long-term memory. The aim of the present study is to characterize the anatomical organization of forward projections that mediate information flow from visual area TE to memory neurons in the PRh cortex. In monkeys performing a visual pair-association memory task, I conducted an extensive mapping of neuronal responses in anteroventral area TE (TEav) and area 36 (A36) of the PRh cortex. Then, three retrograde tracers were separately injected into A36 and the distribution of retrograde labels in TEav was analyzed. I focused on the degree of divergent projections from TEav to memory neurons in A36, because the highly divergent nature of these forward fiber projections has been implicated in memory function. I found that the degree of divergent projection to memory neurons in A36 was smaller from the TEav neurons selective to learned pictures than from the nonselective TEav neurons. This result demonstrates that the anatomical difference (the divergence) correlates with the physiological difference (selectivity of TEav neurons to the learned pictures). Because the physiological difference is attributed to whether or not the projections are involved in information transmission required for memory neurons in A36, it can be speculated that the reduced divergent projection resulted from acquisition of visual long-term memory, possibly through retraction of the projecting axon collaterals.
内容記述: 報告番号: 乙15724 ; 学位授与年月日: 2003-06-18 ; 学位の種別: 論文博士 ; 学位の種類: 博士(医学) ; 学位記番号: 第15724号 ; 研究科・専攻: 医学系研究科
URI: http://hdl.handle.net/2261/51185
出現カテゴリ:021 博士論文
医学

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