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タイトル: Development of a novel mitochondrial cleavage site predictor
著者: Fukasawa, Yoshinori
著者(別言語): 深沢, 嘉紀
キーワード: Mitochondria
Targeting signal
発行日: 2011年9月27日
抄録: A large fraction of mitochondrial proteins are cleaved upon entry into the mitochondria, but prediction of this cleavage is still challenging. In chapter 1, I summarize necessary background to this important problem. In chapter 2, I demonstrate that my system, Mitochondrial matrix targeting Signal Predictor, MoiraiSP, which is based on data from recent proteomic studies can correctly identified the cleavage site of MPP more than 75% accuracy in both plant and yeast dataset. In chapter 3, I introduce sequence divergence, LD(i), as a novel feature for sorting signal prediction, and show that prediction can be improved by LD(i) than random, especially with other famous features such as physico-chemical propensities. In chapter 4, I present that MoiraiSP can treat a related problem, predicting mitochondrial matrix targeting signal by using only N-terminal sequence information such as net-charge or LD(i). MoiraiSP discriminates between cleaved and non-cleaved mitochondrial proteins with a success rate of 97% (plant) or 91% (yeast) by cross validation. Finally, in chapter 5, I discuss some novel candidates of protease substrates, which came up during my work.
内容記述: 報告番号: ; 学位授与年月日: 2011-09-27 ; 学位の種別: 修士 ; 学位の種類: 修士(科学) ; 学位記番号: 修創域第4109号 ; 研究科・専攻: 新領域創成科学研究科情報生命科学専攻
URI: http://hdl.handle.net/2261/52244
出現カテゴリ:025 修士論文
1224125 修士論文(情報生命科学専攻)


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