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タイトル: New stage of the study on domoic acid-producing diatoms : A finding of Nitzschia navis-varingica that produces domoic acid derivatives as major toxin components
著者: Kotaki, Yuichi
Elsa F. Furio
Fe Farida A. Bajarias
Satake, Masayuki
Nina, Lundholm
Koike, Kazuhiko
Sato, Shigeru
Fukuyo, Yasuwo
Kodama, Masaaki
キーワード: domoic acid
isodomoic acid A
isodomoic acid B
Nitzschia navis-varingica
pennate diatom
amnesic shellfish poisoning
発行日: 2006年4月28日
出版者: International Coastal Research Center, Ocean Research Institute, the University of Tokyo
掲載誌情報: Coastal marine science. Vol.30No.1, 2006.4, pp. 116-120
抄録: We reported Nitzschia navis-varingica as a new domoic acid (DA)-producing diatom, and furthermore reported its wide distribution in Asian waters. However the surveys were performed only in limited area of each country. In order to obtain more detailed information, screening of N. navis-varingica was primarily performed in the Philippines. During the survey, we confirmed that all strains of N. navis-varingica isolated from Bulacan, Manila Bay did not produce DA, but did produce isodomoic acids A (IA) and B (IB). The confirmation of IA and IB was done by the analyses of UV-spectra, LC-MS/MS, proton NMR and ^<13>C NMR. Re-observation of the toxin composition including IA and IB simultaneously with DA was performed on the former chromatograms. All the strains positive for DA and/or its derivatives isolated from estuary areas of Bacoor, Tanauan and San Roque, were confirmed to produced DA and IB, indicating that there is a local difference in toxin composition in the Philippines. All of the toxic strains were identified as N. navis-varingica. This is the first report of pennate diatom that produces IA and IB instead of DA as major toxin component. This finding might be a useful step in pursuing the DA production mechanism. Additionally fourty one Pseudo-nitzschia strains isolated from offshore areas of above mentioned estuaries were tested for DA, but all of them did not show any sign of DA production.
URI: http://hdl.handle.net/2261/5619
ISSN: 13493000
出現カテゴリ:Coastal Marine Science
Coastal Marine Science


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