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タイトル: Odorant Concentration Differentiator for Intermittent Olfactory Signals
著者: Fujiwara, Terufumi
Kazawa, Tomoki
Sakurai, Takeshi
Fukushima, Ryota
Uchino, Keiro
Yamagata, Tomoko
Namiki, Shigehiro
Haupt, Stephan Shuichi
Kanzaki, Ryohei
発行日: 2014年12月10日
出版者: Society of Neuroscience
掲載誌情報: The Journal of Neuroscience, 34(50): 16581-16593; doi: 10.1523/JNEUROSCI.2319-14.2014 (2014)
関連URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/a-novel-neuronal-mechanism-to-efficiently-code-odorant-concentration/
抄録: Animals need to discriminate differences in spatiotemporally distributed sensory signals in terms of quality as well as quantity for generating adaptive behavior. Olfactory signals characterized by odor identity and concentration are intermittently distributed in the environment. From these intervals of stimulation, animals process odorant concentration to localize partners or food sources. Although concentration–response characteristics in olfactory neurons have traditionally been investigated using single stimulus pulses, their behavior under intermittent stimulus regimens remains largely elusive. Using the silkmoth (Bombyx mori) pheromone processing system, a simple and behaviorally well-defined model for olfaction, we investigated the neuronal representation of odorant concentration upon intermittent stimulation in the naturally occurring range. To the first stimulus in a series, the responses of antennal lobe (AL) projection neurons (PNs) showed a concentration dependence as previously shown in many olfactory systems. However, PN response amplitudes dynamically changed upon exposure to intermittent stimuli of the same odorant concentration and settled to a constant, largely concentration-independent level. As a result, PN responses emphasized odorant concentration changes rather than encoding absolute concentration in pulse trains of stimuli. Olfactory receptor neurons did not contribute to this response transformation which was due to long-lasting inhibition affecting PNs in the AL. Simulations confirmed that inhibition also provides advantages when stimuli have naturalistic properties. The primary olfactory center thus functions as an odorant concentration differentiator to efficiently detect concentration changes, thereby improving odorant source orientation over a wide concentration range.
内容記述: UTokyo Research掲載「匂いの濃度を効率的に表現する脳の計算メカニズムの発見」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/a-novel-neuronal-mechanism-to-efficiently-code-odorant-concentration/
UTokyo Research "A novel neuronal mechanism to efficiently code odorant concentration" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/a-novel-neuronal-mechanism-to-efficiently-code-odorant-concentration/
URI: http://hdl.handle.net/2261/56875
ISSN: 0270-6474(print)
出現カテゴリ:014 自然科学
14010 学術雑誌論文


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