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タイトル: Desynchronization of cerebellar Purkinje cell population activity during postnatal development
その他のタイトル: 生後発達期における小脳プルキンエ細胞集団活動の非同期化
著者: Jean-Marc, Good
著者(別言語): ジャンマルク, グッド
発行日: 2013年3月25日
抄録: The inferior olive of the medulla oblongata sends glutamatergic afferents to the cerebellum. In adult rodents, axons of inferior olivary neurons divide into several climbing fibers (CFs) that innervate cerebellar Purkinje cells (PCs) in a one-to-one manner. Activation of CFs generates bursts of action potentials known as complex spikes (CSs) in PCs. CSs in neighboring PCs are synchronized due to electrical coupling between inferior olivary neurons. During early postnatal period, however, the pattern of CS activity in populations of PCs remains unclear. CF-PC synapses undergo dynamic changes during the first two postnatal weeks including selective strengthening of a single CF and elimination of redundant CFs in each PC. In this study, I used in vivo two-photon calcium imaging to monitor CS activity from populations of PCs during the period of the CF network refinement. I found that CS activity was highly correlated among neighboring PCs in newborn mice and progressively desynchronized during the first postnatal week. The degree of synchrony declined to the adult level at postnatal day 8. I also analyzed PC-specific Cav 2.1 knockout mouse, in which selective strengthening of a single CF and elimination of redundant CFs in each PC is impaired. The progressive desynchronization of CS activity observed in wild-type mice was incomplete in the knockout mice. These results suggest that the configuration of the CF network has a direct impact on the pattern of CS activity in PC populations and that the desynchronization of CS activity might result from the CF network refinement.
内容記述: 報告番号: ; 学位授与年月日: 2013-03-25 ; 学位の種別: 課程博士 ; 学位の種類: 博士(医学) ; 学位記番号: ; 研究科・専攻: 医学系研究科機能生物学専攻
URI: http://hdl.handle.net/2261/59327
出現カテゴリ:021 博士論文
1120420 博士論文(機能生物学専攻)

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