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タイトル: Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
著者: Hashidume, Tsutomu
Kato, Asuka
Tanaka, Tomohiro
Miyoshi, Shoko
Itoh, Nobuyuki
Nakata, Rieko
Inoue, Hiroyasu
Oikawa, Akira
Nakai, Yuji
Shimizu, Makoto
Inoue, Jun
Sato, Ryuichiro
キーワード: Metabolic syndrome
Molecular biology
発行日: 2016年6月17日
出版者: Nature Publishing Group
掲載誌情報: Tsutomu Hashidume, Asuka Kato, Tomohiro Tanaka, Shoko Miyoshi, Nobuyuki Itoh, Rieko Nakata, Hiroyasu Inoue, Akira Oikawa, Yuji Nakai, Makoto Shimizu, Jun Inoue and Ryuichiro Sato, "Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects", Scientific Reports Online Edition: 2016/06/17 (Japan time), doi:10.1038/srep28183.
関連URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html
抄録: Soy protein β-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that single ingestion of β-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating transcription factor 4 (ATF4), but not for peroxisome proliferator-activated receptor α. Overexpression of a dominant-negative form of ATF4 significantly reduced β-conglycinin-induced increases in hepatic FGF21 gene expression. In FGF21-deficient mice, β-conglycinin effects were partially abolished. Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling. Thus, dietary β-conglycinin intake can impact hepatic and systemic metabolism by increasing the postprandial circulating FGF21 levels.
内容記述: UTokyo Research掲載「大豆のタンパク質1回摂取で代謝を改善する因子が急増」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html
UTokyo Research "Single ingestion of soy protein improves metabolism" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html
URI: http://hdl.handle.net/2261/59542
ISSN: 2045-2322 (online)
出現カテゴリ:014 自然科学
1160410 学術雑誌論文


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