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タイトル: The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice
著者: Akamatsu, Megumi
Yamashita, Takenari
Hirose, Naoki
Teramoto, Sayaka
Kwak, Shin
キーワード: Amyotrophic lateral sclerosis
発行日: 2016年6月28日
出版者: Nature Publishing Group
掲載誌情報: Megumi Akamatsu, Takenari Yamashita, Naoki Hirose, Sayaka Teramoto, Shin Kwak, "The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice", Scientific Reports Online Edition: 2016/06/28 (Japan time), doi:10.1038/srep28649.
関連URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/finding-a-treatment-for-als.html
抄録: Both TDP-43 pathology and failure of RNA editing of AMPA receptor subunit GluA2, are etiology-linked molecular abnormalities that concomitantly occur in the motor neurons of the majority of patients with amyotrophic lateral sclerosis (ALS). AR2 mice, in which an RNA editing enzyme adenosine deaminase acting on RNA 2 (ADAR2) is conditionally knocked out in the motor neurons, exhibit a progressive ALS phenotype with TDP-43 pathology in the motor neurons through a Ca2+-permeable AMPA receptor-mediated mechanism. Therefore, amelioration of the increased Ca2+ influx by AMPA receptor antagonists may be a potential ALS therapy. Here, we showed that orally administered perampanel, a selective, non-competitive AMPA receptor antagonist significantly prevented the progression of the ALS phenotype and normalized the TDP-43 pathology-associated death of motor neurons in the AR2 mice. Given that perampanel is an approved anti-epileptic drug, perampanel is a potential candidate ALS drug worthy of a clinical trial.
内容記述: UTokyo Research掲載「筋萎縮性側索硬化症の治療法に向けて」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/finding-a-treatment-for-als.html
UTokyo Research "Finding a treatment for ALS" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/finding-a-treatment-for-als.html
URI: http://hdl.handle.net/2261/59543
ISSN: 2045-2322 (online)
出現カテゴリ:014 自然科学
11210 学術雑誌論文


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