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Effect of a glycine residue insertion into crustacean hyperglycemic hormone on hormonal activity
http://hdl.handle.net/2261/8076
http://hdl.handle.net/2261/8076e334ae9d-bc1f-4730-bfd2-0563adf514b0
名前 / ファイル | ライセンス | アクション |
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ZS21_1121.pdf (125.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-12-14 | |||||
タイトル | ||||||
タイトル | Effect of a glycine residue insertion into crustacean hyperglycemic hormone on hormonal activity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | crustacean hyperglycemic hormone | |||||
主題Scheme | Other | |||||
キーワード | ||||||
主題 | kuruma prawn | |||||
主題Scheme | Other | |||||
キーワード | ||||||
主題 | mutational analysis | |||||
主題Scheme | Other | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Katayama, Hidekazu
× Katayama, Hidekazu× Nagasawa, Hiromichi |
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著者別名 | ||||||
識別子 | 105907 | |||||
識別子Scheme | WEKO | |||||
姓名 | 長澤, 寛道 | |||||
著者所属 | ||||||
著者所属 | Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo | |||||
著者所属 | ||||||
著者所属 | Institute for Protein Research, Osaka University | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Crustacean hyperglycemic hormone (CHH) and molt-inhibiting hormone (MIH) have similar amino acid sequences and therefore comprise a peptide family referred to as the CHH family. All MIHs unexceptionally have an additional glycine residue at position 12, which is lacking in all CHHs. In order to understand the relevance of the absence of the glycine residue for hyperglycemic activity, a mutant CHH having a glycine residue insertion was prepared, and its hyperglycemic activity was assessed. This mutant CHH had the same disulfide bond arrangement as the recombinant CHH produced in Escherichia coli cells, and exhibited a similar circular dichroism spectrum to the recombinant CHH, indicating that the two CHHs possessed similar conformations. The mutant CHH showed a hyperglycemic effect weaker than the recombinant CHH by about one order of magnitude. These results suggest that the insertion of a glycine residue is one of the indices for structural and functional divergence of the CHH family peptides. | |||||
書誌情報 |
Zoological science 巻 21, 号 11, p. 1121-1124, 発行日 2004 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02890003 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10545874 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.2108/zsj.21.1121 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
日本十進分類法 | ||||||
主題 | 480 | |||||
主題Scheme | NDC | |||||
出版者 | ||||||
出版者 | Zoological Society of Japan | |||||
出版者別名 | ||||||
日本動物学会 |