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TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling
http://hdl.handle.net/2261/00077254
http://hdl.handle.net/2261/00077254acebb9fe-e75f-489d-b66b-6485ea4408bb
| 名前 / ファイル | ライセンス | アクション |
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s41421-017-0001-2.pdf (2.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-07-23 | |||||
| タイトル | ||||||
| タイトル | TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Kawasaki, Natsumi
× Kawasaki, Natsumi× Isogaya, Kazunobu× Dan, Shingo× Yamori, Takao× Takano, Hiroshi× Yao, Ryoji× Morishita, Yasuyuki× Taguchi, Luna× Morikawa, Masato× Heldin, Carl-Henrik× Noda, Tetsuo× Ehata, Shogo× Miyazono, Kohei× Koinuma, Daizo |
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| 著者所属 | ||||||
| 著者所属 | Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research | |||||
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| 著者所属 | Division of Cell Biology and Director’s Room, Cancer Institute, Japanese Foundation for Cancer Research | |||||
| 著者所属 | ||||||
| 著者所属 | Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University | |||||
| 著者所属 | ||||||
| 著者所属 | Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regulated by Rab GTPases. Here we showed that tuftelin 1 (TUFT1) was involved in the activation of mTORC1 through modulating the Rab GTPase-regulated process. TUFT1 promoted tumor growth and metastasis. Consistently, the expression of TUFT1 correlated with poor prognosis in lung, breast and gastric cancers. Mechanistically, TUFT1 physically interacted with RABGAP1, thereby modulating intracellular lysosomal positioning and vesicular trafficking, and promoted mTORC1 signaling. In addition, expression of TUFT1 predicted sensitivity to perifosine, an alkylphospholipid that alters the composition of lipid rafts. Perifosine treatment altered the positioning and trafficking of cellular compartments to inhibit mTORC1. Our observations indicate that TUFT1 is a key regulator of the mTORC1 pathway and suggest that it is a promising therapeutic target or a biomarker for tumor progression. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo FOCUS Articles掲載「がんの増殖・転移を促進する新規因子の同定 小胞輸送を標的とする新しいがん治療戦略への可能性」 https://www.u-tokyo.ac.jp/focus/ja/articles/z0508_00119.html | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo FOCUS Articles "Possible target for future cancer treatment : Deregulation of system to move molecules in the cell may promote tumor growth, metastasis" https://www.u-tokyo.ac.jp/focus/en/articles/z0508_00120.html | |||||
| 書誌情報 |
Cell Discovery 巻 4, 号 1, 発行日 2018-01-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2056-5968 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1038/s41421-017-0001-2 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2018 | |||||
| 権利 | ||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changesweremade. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.u-tokyo.ac.jp/focus/ja/articles/z0508_00119.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.u-tokyo.ac.jp/focus/en/articles/z0508_00120.html | |||||
| 関係URI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41421-017-0001-2 | |||||
