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6-\u30c8\u30ea\u30cb\u30c8\u30ed\u30af\u30ed\u30ed\u30d9\u30f3\u30bc\u30f3(TNCB)\u306b\u3088\u308bCHS\u306f\u6b63\u5e38\u306b\u8a98\u5c0e\u3055\u308c\u308b\u304c\u3001\u4f4e\u6fc3\u5ea6\u306eTNCB\u3067\u306e\u307f\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u6b20\u640d\u30de\u30a6\u30b9\u306e\u7d50\u679c\u304b\u3089\u3082TNF\u03b1\u3068IL-1\u03b2\u304cCHS\u306e\u767a\u75c7\u306b\u4f55\u3089\u304b\u306e\u5f79\u5272\u3092\u6f14\u3058\u3066\u3044\u308b\u3053\u3068\u306f\u660e\u767d\u3067\u3042\u308b\u304c\u3001IL-1\u03b1\u306e\u5f79\u5272\u3084\u985e\u4f3c\u306e\u4f5c\u7528\u3092\u793a\u3059\u305d\u308c\u30893\u3064\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7279\u7570\u7684\u3042\u308b\u3044\u306f\u76f8\u88dc\u7684\u306a\u4f5c\u7528\u306e\u660e\u78ba\u306a\u533a\u5206\u306b\u3064\u3044\u3066\u306f\u5168\u304f\u7406\u89e3\u3055\u308c\u3066\u3044\u306a\u3044\u3002//\u3000\u9ad8\u6fc3\u5ea6TNCB\u611f\u4f5c\u306b\u3088\u308bCHS\u306e\u767a\u75c7\u306f\u3001IL-1\u03b2\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3059\u3067\u306b\u5831\u544a\u304c\u3042\u308b\u3088\u3046\u306b\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3068\u540c\u30ec\u30d9\u30eb\u306e\u8a98\u5c0e\u304c\u898b\u3089\u308c\u308b\u306e\u306b\u5bfe\u3057\u3001IL-1\u03b1\u6b20\u640d\u30de\u30a6\u30b9\u3068IL-1\u03b1/\u03b2\u6b20\u640d\u30de\u30a6\u30b9\u306f\u540c\u7a0b\u5ea6\u306e\u6291\u5236\u3092\u8a8d\u3081\u305f\u3002CHS\u306e\u767a\u75c7\u306b\u304a\u3044\u3066\u3001\u76ae\u819a\u304b\u3089\u5f93\u5c5e\u30ea\u30f3\u30d1\u7bc0\u3078\u79fb\u52d5\u3057\u305f\u6210\u719fLC\u304cIL-1\u03b1\u3092\u7523\u751f\u3057\u3001\u305d\u306eIL-1\u03b1\u304c\u30cf\u30d7\u30c6\u30f3\u7279\u7570\u7684\u306aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u4e00\u65b9\u3001IL-1\u03b2\u306f\u30cf\u30d7\u30c6\u30f3\u7279\u7570\u7684\u306aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3088\u308a\u3082\u3080\u3057\u308d\u30cf\u30d7\u30c6\u30f3\u7279\u7570\u7684\u306a\u6297\u4f53\u7523\u751f\u5fdc\u7b54\u306e\u4fc3\u9032\u306b\u6df1\u304f\u95a2\u308f\u308a\u3001CHS\u3067\u60f9\u8d77\u3055\u308c\u308b\u514d\u75ab\u5fdc\u7b54\u306b\u304a\u3044\u3066IL-1\u03b1\u3068IL-1\u03b2\u306e\u4f5c\u7528\u306b\u5927\u304d\u306a\u7279\u7570\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u307e\u305f\u3001TNF\u03b1\u6b20\u640d\u30de\u30a6\u30b9\u3082IL-1\u03b1/\u03b2\u6b20\u640d\u30de\u30a6\u30b9\u3068\u540c\u7a0b\u5ea6\u306eCHS\u306e\u767a\u75c7\u306e\u6291\u5236\u3092\u8a8d\u3081\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001TNF\u03b1\u6b20\u640d\u30de\u30a6\u30b9\u306fIL-1\u03b1/\u03b2\u6b20\u640d\u30de\u30a6\u30b9\u3068\u7570\u306a\u308a\u3001\u30cf\u30d7\u30c6\u30f3\u7279\u7570\u7684\u306aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306f\u6b63\u5e38\u306b\u8a98\u5c0e\u3055\u308c\u3001IL-1\u306e\u4f5c\u7528\u3068\u306f\u7570\u306a\u308bTNF\u03b1\u306b\u3088\u308bCHS\u8a98\u5c0e\u306e\u5206\u5b50\u6a5f\u69cb\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002IL-1\u306f\u30a2\u30ec\u30eb\u30b2\u30f3\u611f\u4f5c\u6642\u306e\u30cf\u30d7\u30c6\u30f3\u7279\u7570\u7684\u306aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u518d\u611f\u4f5c\u6642\u306e\u76ae\u819a\u5c40\u6240\u3067\u306eTNF\u03b1\u306e\u7523\u751f\u306b\u5fc5\u8981\u3067\u3001\u5c40\u6240\u3067\u7523\u751f\u3055\u308c\u305fTNF\u03b1\u306f\u708e\u75c7\u6027\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u306e\u5c40\u6240\u3078\u306e\u6d78\u6f64\u306b\u95a2\u308f\u308b\u63a5\u7740\u5206\u5b50\u3084\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u8a98\u5c0e\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u4e2d\u3067\u3082\u3001TNF\u03b1\u306f\u76ae\u819a\u306e\u7d30\u80de\u306b\u76f4\u63a5\u7684\u306b\u4f5c\u7528\u3057\u3066\u6d3b\u6027\u5316T\u7d30\u80de\u306e\u6d78\u6f64\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u3082\u3064Interferon-\u03b3(IFN-\u03b3)-inducible protein 10 kDa (IP-10)\u306e\u767a\u73fe\u3092IFN-\u03b3\u306e\u4f5c\u7528\u3068\u306f\u975e\u4f9d\u5b58\u7684\u306b\u4ea2\u9032\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001CHS\u306b\u304a\u3051\u308b\u6162\u6027\u708e\u75c7\u5fdc\u7b54\u306e\u8a98\u5c0e\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002//3)IL-17\u6b20\u640d\u30de\u30a6\u30b9\u306e\u4f5c\u88fd\u3068T\u7d30\u80de\u4f9d\u5b58\u6027\u514d\u75ab\u5fdc\u7b54\u306b\u304a\u3051\u308bIL-17\u306e\u5f79\u5272//\u3000IL-17\u306f1993\u5e74\u306bcytotoxic T lymphocyte associated antigen-8\u3068\u3057\u3066T\u7d30\u80de\u306e\u30b5\u30d6\u30c8\u30e9\u30af\u30b7\u30e7\u30f3cDNA\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u304b\u3089\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u3001Herpesvirus saimiri\u306eopen reading frame 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