{"created":"2021-03-01T06:18:55.733349+00:00","id":2322,"links":{},"metadata":{"_buckets":{"deposit":"612f29bc-3b05-4878-8564-e64b62a16cfb"},"_deposit":{"id":"2322","owners":[],"pid":{"revision_id":0,"type":"depid","value":"2322"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00002322","sets":["125:355:356","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-23","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2009-03-23"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"慢性移植片対宿主病(chronic graft-versus-host disease; cGVHD)は同種異系骨髄移植(allogeneic bone marrow transplantation; alloBMT)における罹患・死亡の主要な原因となっているが、有効な治療戦略は未だ確立されていない。本研究では、マウス骨髄由来樹状細胞(dendritic cells; DCs)を改変してこれまでに知られている免疫寛容誘導性樹状細胞よりも強力な免疫制御能をもつ制御性樹状細胞(regulatory DCs; DCregs)を作製し、マウス主要組織適合抗原複合体一致・マイナー組織適合抗原不一致alloBMT実験モデルにおけるcGVHDに対するDCregsの治療効果について検討を行った。//alloBMT後のレシピエントマウスへのレシピエントタイプ活性化成熟樹状細胞(mature DCs; mDCs)の投与では皮膚cGVHDが増悪したが、レシピエントタイプDCregsの投与では免疫抑制剤ラパマイシンよりも皮膚cGVHDに対する著明な防御効果が認められた。さらに、レシピエントマウスの解析によりレシピエントタイプDCregsのcGVHD防御効果にはドナーマウス由来の同種異系反応性CD4+CD25-Foxp3-T細胞からCD4+CD25+Foxp3+制御性T(regulatory T; TR)細胞への末梢誘導が関与していることが示唆された。//以上の結果から、alloBMTでのcGVHDに対するDCregsを用いた免疫細胞療法はCD4+CD25+Foxp3+TR細胞による免疫寛容の誘導を介した有用な治療戦略として期待された","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第24861号"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00002316","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science (医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Internal Medicine, Graduate School of Medicine (医学系研究科内科学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3281号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科内科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤田, 成晴"}],"nameIdentifiers":[{"nameIdentifier":"6523","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-31"}],"displaytype":"detail","filename":"41_fujita..pdf","filesize":[{"value":"951.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"41_fujita..pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/2322/files/41_fujita..pdf"},"version_id":"67f61d5c-719a-4178-b54a-e3e7ecfcee16"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"制御性樹状細胞によるCD4+CD25+Foxp3+制御性T細胞の誘導を介した皮膚慢性移植片対宿主病に対する防御効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"制御性樹状細胞によるCD4+CD25+Foxp3+制御性T細胞の誘導を介した皮膚慢性移植片対宿主病に対する防御効果"}]},"item_type_id":"7","owner":"1","path":["280","356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-03-01"},"publish_date":"2012-03-01","publish_status":"0","recid":"2322","relation_version_is_last":true,"title":["制御性樹状細胞によるCD4+CD25+Foxp3+制御性T細胞の誘導を介した皮膚慢性移植片対宿主病に対する防御効果"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:43:59.474828+00:00"}