{"created":"2021-03-01T06:19:03.813923+00:00","id":2454,"links":{},"metadata":{"_buckets":{"deposit":"4c204dfd-d4ea-45e9-9a02-b52fe320307b"},"_deposit":{"id":"2454","owners":[],"pid":{"revision_id":0,"type":"depid","value":"2454"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00002454","sets":["125:355:356","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗核抗体は膠原病における全身性自己免疫の代表的現象であり、腎炎など病態形成への関与も指摘されている。その機序には不明な点が多く、動物モデルの有用性が限定的であることも研究の障害となっている。この解決のため、本研究は、制御性T細胞を欠いたCD4+T細胞のヌードマウスへの移入が、全例に早期より長期間持続する高抗体価の抗核抗体を誘導し、容易に誘導環境を変更できる有用な系であることを見出した。さらに本系を用いて、リンパ球減少下では末梢リンパ球が増殖し再構築する生理的なhomeostatic proliferationという機構が、germinal center形成とfollicular helper T細胞の誘導とともに抗核抗体誘導能を内在しており、その危険を制御性T細胞が抑制していることを明らかにした。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第25957号"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00002448","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science (医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Internal Medicine, Graduate School of Medicine (医学系研究科内科学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3436号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"大学院医学系研究科 内科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"神崎, 健仁"}],"nameIdentifiers":[{"nameIdentifier":"6737","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-31"}],"displaytype":"detail","filename":"h21_kanzaki.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h21_kanzaki.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/2454/files/h21_kanzaki.pdf"},"version_id":"6c964b15-2a4b-40c3-a041-0dc99a6f3dc8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-31"}],"displaytype":"detail","filename":"h21_kanzaki_a.pdf","filesize":[{"value":"165.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h21_kanzaki_a.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/2454/files/h21_kanzaki_a.pdf"},"version_id":"d2a25852-8554-48d3-a9f5-48391d8247d5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"リンパ球移入による全身性自己免疫疾患動物モデルの樹立と抗核抗体産生機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リンパ球移入による全身性自己免疫疾患動物モデルの樹立と抗核抗体産生機序の解明"}]},"item_type_id":"7","owner":"1","path":["280","356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-03-01"},"publish_date":"2012-03-01","publish_status":"0","recid":"2454","relation_version_is_last":true,"title":["リンパ球移入による全身性自己免疫疾患動物モデルの樹立と抗核抗体産生機序の解明"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:44:16.573245+00:00"}