{"created":"2021-03-01T06:19:03.997395+00:00","id":2457,"links":{},"metadata":{"_buckets":{"deposit":"d292ed9f-e7db-47d0-83c8-481af135c2e6"},"_deposit":{"id":"2457","owners":[],"pid":{"revision_id":0,"type":"depid","value":"2457"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00002457","sets":["125:355:356","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アポトーシスは最終的に蛋白分解酵素である実行カスパーゼが活性化し、特定の蛋白質（デスサブストレイト）を分解することにより進行する。我々は癌抑制蛋白hScrib のアポトーシスへの関与とその機能を検討した。hScrib はアポトーシスが進行する過程で実行カスパーゼ、特にカスパーゼ3 によって分解を受けるデスサブストレイトであることがわかった。hScrib におけるカスパーゼ3 の切断部位は504 番目のアミノ酸のC 末側である。この部位は細胞接着に関わる蛋白複合体を崩壊させるのに効果的な切断部位であることが推測される。アポトーシスが進行する過程でhScrib が分解されることによりアドヘレンスジャンクションを形成する蛋白質の分解が進行し、細胞接着の崩壊が促されることによって異常細胞を正常細胞から離解させるというシステムの可能性が示された。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第26009号"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00002451","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science (医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Internal Medicine, Graduate School of Medicine (医学系研究科内科学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3488号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"大学院医学系研究科 生殖・発達・加齢医学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"曾根, 献文"}],"nameIdentifiers":[{"nameIdentifier":"6740","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-31"}],"displaytype":"detail","filename":"h21_sone.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h21_sone.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/2457/files/h21_sone.pdf"},"version_id":"e375f52e-8119-42c2-b638-b481fd32b76d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-31"}],"displaytype":"detail","filename":"h21_sone_a.pdf","filesize":[{"value":"144.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h21_sone_a.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/2457/files/h21_sone_a.pdf"},"version_id":"2479d34b-a6fe-4db7-8a46-ecfcccf84864"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"癌抑制蛋白hScrib のアポトーシスへの関与とその機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌抑制蛋白hScrib のアポトーシスへの関与とその機能解析"}]},"item_type_id":"7","owner":"1","path":["280","356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-03-01"},"publish_date":"2012-03-01","publish_status":"0","recid":"2457","relation_version_is_last":true,"title":["癌抑制蛋白hScrib のアポトーシスへの関与とその機能解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:44:15.589802+00:00"}