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cd5\u306b\u3088\u308a\u63a8\u5b9a\u3059\u308b\u3002\u8cea\u7684\u5f62\u8cea(\u884c\u52d5\u4e0a\u306e\u554f\u984c)\u306b\u95a2\u3057\u3066\u306f\u3001\u76f8\u95a2\u4fc2\u6570(tetrachoric correlation)\u884c\u5217\u3092\u3001\u91cf\u7684\u5f62\u8cea(\u904b\u52d5\u306e\u767a\u9054\u30fb\u3053\u3068\u3070\u306e\u767a\u9054)\u306b\u95a2\u3057\u3066\u306f\u3001\u5206\u6563/\u5171\u5206\u6563\u884c\u5217\u3092\u7528\u3044\u305f\u3002//\u3000\u4eca\u56de\u306e\u89e3\u6790\u306b\u7528\u3044\u305f\u907a\u4f1d\u30e2\u30c7\u30eb\u306f\u672c\u8cea\u7684\u306b\u306f[1]1\u5909\u6570\u306b\u95a2\u3059\u308b\u30e2\u30c7\u30eb\u3001(1)Univariate Genetic Model\u3001(2)General Sex-limitation Model\u3001(3)Scalar Sex-limitation Model\u3001[2]\u591a\u5909\u6570\u306b\u95a2\u3059\u308b\u30e2\u30c7\u30eb\u3001(1)Simple Genetic Factor Model\u3001(2)Genetic Cholesky Decomposition Model\u3001(3)Independent Pathway Model\u3001(4)Common Pathway Model\u3001[3]2\u5909\u6570\u9593\u306e\u56e0\u679c\u95a2\u4fc2\u306b\u95a2\u3059\u308b\u30e2\u30c7\u30eb(1)Reciprocal Causation Model\u3001(2)Genetic Bivariate Model\u306b\u96c6\u7d04\u3055\u308c\u308b\u3002\u89e3\u6790\u306b\u306f\u3001\u6c4e\u7528\u30bd\u30d5\u30c8PLELIS2,LISREL8\u3092\u7528\u3044\u305f\u3002//4.\u7d50\u679c(1)\u884c\u52d5\u4e0a\u306e\u554f\u984c\u306b\u95a2\u3059\u308b\u89e3\u6790\u7d50\u679c//\u3000\u6700\u9069\u3068\u8003\u3048\u3089\u308c\u305f\u30e2\u30c7\u30eb\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u3063\u305f\u3002\u300c\u5403\u97f3\u300d\u300c\u30c1\u30c3\u30af\u300d\u3067\u306f\u3001\u5168\u30c7\u30fc\u30bf\u3092\u8aac\u660e\u3057\u3046\u308b\u30e2\u30c7\u30eb\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u305d\u308c\u4ee5\u5916\u306fA,C,E\u3092\u57fa\u672c\u6210\u5206\u3068\u3057\u3066\u542b\u3080\u30e2\u30c7\u30eb\u304c\u9069\u5408\u3057\u305f\u3002Scalar ACE Model\u304c\u9069\u5408\u3057\u305f\u300c\u5bdd\u8a00\u300d\u300c\u591c\u9a5a\u300d\u300c\u722a\u304b\u307f\u300d\u3067\u306f\u3001\u7537\u5973\u3067\u5dee\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u907a\u4f1d\u7387(A\u306e\u5272\u5408)\u304c\u5927\u304d\u3044\u5f62\u8cea\u306f\u3001\u300c\u5bdd\u8a00\u300d\u300c\u5bdd\u307c\u3051\u300d\u300c\u591c\u9a5a\u300d\u3067\u3042\u308a\u3001\u300c\u5bdd\u307c\u3051\u300d\u3067\u306f\u5973\u5b50\u306e\u907a\u4f1d\u7387\u304c\u7537\u5b50\u306e\u907a\u4f1d\u7387\u3088\u308a\u308210%\u4ee5\u4e0a\u5927\u304d\u3044\u5024\u3092\u793a\u3057\u305f\u3002\u300c\u591c\u5c3f\u300d\u306b\u95a2\u3057\u3066\u306f\u3001\u5168\u4f53\u7684\u306b\u898b\u308b\u3068\u5973\u5b50\u3067\u306f\u5171\u6709\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u304c60%\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u304c\u3001\u7537\u5b50\u3067\u306f\u76f8\u52a0\u7684\u907a\u4f1d\u8981\u56e0\u3001\u5171\u6709\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u305d\u308c\u305e\u308c45%\u524d\u5f8c\u3068\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002//\u3000\u300c\u591c\u5c3f\u300d\u3092\u5e74\u9f62\u5225\u306b\u898b\u308b\u3068\u3001\u7537\u5b50\u3067\u5e74\u9f62\u306b\u3088\u308b\u907a\u4f1d\u7387\u306e\u5dee\u306f\u5c0f\u3055\u304b\u3063\u305f\u304c\u3001\u5973\u5b50\u3067\u306f\u5e74\u9f62\u3068\u3068\u3082\u306b\u907a\u4f1d\u7387\u304c\u4e0a\u6607\u3059\u308b\u50be\u5411\u304c\u898b\u3089\u308c\u305f\u30023\u6b73\u30014\u6b73\u3067\u306f\u7537\u5b50\u306e\u907a\u4f1d\u7387\u304c\u30015\u6b73\u4ee5\u964d\u3067\u306f\u5973\u5b50\u306e\u907a\u4f1d\u7387\u304c\u5927\u304d\u304b\u3063\u305f\u3002//\u3000\u7761\u7720\u6642\u306e\u884c\u52d5\u4e0a\u306e\u554f\u984c\u306eMultivariate Genetic Model\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u7537\u5b50\u3067\u306fIndependent Pathway AE Model\u304c\u3001\u5973\u5b50\u3067\u306fIndependent Pathway ACE Model\u304c\u9069\u5408\u3057\u305f\u3002\u7537\u5973\u3068\u3082\u306b\u3001\u5f62\u8cea\u306b\u7279\u7570\u7684\u306a\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u5927\u304d\u304b\u3063\u305f\u3002\u7537\u5b50\u3067\u306f\u3001\u5f62\u8cea\u7279\u7570\u7684\u306a\u76f8\u52a0\u7684\u907a\u4f1d\u8981\u56e0\u306e\u95a2\u4e0e\u306f\u300c\u591c\u9a5a\u300d\u300c\u591c\u5c3f\u300d\u3067\u304a\u3088\u305d50%\u3001\u300c\u5bdd\u8a00\u300d\u300c\u5bdd\u307c\u3051]\u306730%\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\u300c\u591c\u5c3f\u300d\u306b\u95a2\u3057\u3066\u306f\u3001\u5171\u901a\u8981\u56e0\u306e\u95a2\u4e0e\u306f\u5c0f\u3055\u304b\u3063\u305f\u3002\u5973\u5b50\u3067\u306f\u3001\u5f62\u8cea\u306b\u7279\u7570\u7684\u306a\u76f8\u52a0\u7684\u907a\u4f1d\u8981\u56e0\u306e\u95a2\u4e0e\u306f\u300c\u5bdd\u8a00\u300d\u306735%\u7a0b\u5ea6\u3001\u300c\u591c\u5c3f\u300d\u306750%\u3001\u300c\u5bdd\u307c\u3051\u300d\u300c\u591c\u9a5a\u300d\u3067\u306f0%\u3067\u3042\u3063\u305f\u3002\u5171\u901a\u8981\u56e0\u306b\u95a2\u3057\u3066\u306f\u3001\u76f8\u52a0\u7684\u907a\u4f1d\u8981\u56e0\u306e\u5272\u5408\u306f\u300c\u5bdd\u8a00\u300d\u306727%\u3001\u300c\u5bdd\u307c\u3051\u300d\u306738%\u3001\u300c\u591c\u9a5a\u300d\u306725%\u3001\u300c\u591c\u5c3f\u300d\u3067\u306f0%\u3067\u3042\u3063\u305f\u3002\u300c\u591c\u5c3f\u300d\u306b\u95a2\u3057\u3066\u306f\u7537\u5b50\u3068\u540c\u69d8\u306b\u3001\u5171\u901a\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u5c0f\u3055\u304b\u3063\u305f\u3002//\u3000\u5c0f\u5150\u671f\u306e\u884c\u52d5\u4e0a\u306e\u554f\u984c\u3068\u306a\u308b2\u5f62\u8cea\u9593\u306eTetrachoric Correlation\u3092\u7b97\u51fa\u3057\u305f\u7d50\u679c\u3001\u7761\u7720\u6642\u306e\u884c\u52d5\u4e0a\u306e\u554f\u984c\u306e\u9593\u306b\u5f37\u3044\u76f8\u95a2\u304c\u898b\u3089\u308c\u308b\u50be\u5411\u306b\u3042\u3063\u305f\u3002Bivariate Genetic Model\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u7537\u5b50\u3067\u306f\u300c\u5bdd\u8a00-\u591c\u5c3f\u300d\u300c\u5bdd\u307c\u3051-\u591c\u9a5a\u300d\u306eCholesky ACE Model\u3067\u6bd4\u8f03\u7684\u3088\u3044\u9069\u5408\u3092\u793a\u3057\u305f\u3002\u5973\u5b50\u3067\u306f\u300c\u5bdd\u8a00-\u591c\u5c3f\u300d\u300c\u5bdd\u307c\u3051-\u591c\u5c3f\u300d\u306eCholesky ACE Model\u3067\u3088\u3044\u9069\u5408\u3092\u793a\u3057\u305f\u3002//(2)\u904b\u52d5\u306e\u767a\u9054\u30fb\u3053\u3068\u3070\u306e\u767a\u9054\u306b\u95a2\u3059\u308b\u89e3\u6790\u7d50\u679c//\u3000Univariate Genetic Model\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u7537\u5973\u3068\u3082\u306b\u5168\u3066\u306e\u9805\u76ee\u3067ACE Model\u304c\u63a1\u629e\u3055\u308c\u305f\u3002\u5168\u822c\u7684\u306b\u5171\u6709\u74b0\u5883\u8981\u56e0\u306e\u5f71\u97ff\u304c\u6700\u3082\u5927\u304d\u304f\u3001\u76f8\u52a0\u7684\u907a\u4f1d\u8981\u56e0\u306e\u95a2\u4e0e\u306f30%\u524d\u5f8c\u304c\u591a\u304b\u3063\u305f\u3002\u975e\u5171\u6709\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u306e\u7a0b\u5ea6\u306f\u6570%\u306b\u3059\u304e\u306a\u304b\u3063\u305f\u3002Sex-limitation Model\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u904b\u52d5\u306e\u767a\u9054\u306b\u95a2\u3057\u3066\u306fScalar ACE Model\u3001Common Effects ACE Model\u3001Sex-limitation ACEA\u2019Model\u304c\u6bd4\u8f03\u7684\u3088\u304f\u9069\u5408\u3057\u305f\u3002\u300c\u7247\u8a00\u3092\u3044\u3046\u300d\u306b\u95a2\u3057\u3066\u306f\u3001ACEA\u2019m Model\u306f\u826f\u304f\u9069\u5408\u3057\u305f\u304c\u3001ACEA\u2019f Model\u306f\u307e\u3063\u305f\u304f\u9069\u5408\u3057\u306a\u304b\u3063\u305f\u3002\u300c\u9996\u306e\u3059\u308f\u308a\u300d\u3068\u300c\u306f\u3044\u306f\u3044\u300d\u3067\u306f\u7537\u5973\u5dee\u304c\u5c0f\u3055\u304f\u3001\u5171\u901a\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u5927\u304d\u304b\u3063\u305f\u3002\u300c\u3064\u304b\u307e\u308a\u7acb\u3061\u300d\u300c\u3072\u3068\u308a\u6b69\u304d\u300d\u300c\u7247\u8a00\u3092\u3044\u3046\u300d\u3067\u306f\u7537\u5b50\u306e\u907a\u4f1d\u7387\u304c\u5973\u5b50\u3088\u308a\u308210%\u4ee5\u4e0a\u5927\u304d\u304b\u3063\u305f\u3002//\u3000\u904b\u52d5\u306e\u767a\u9054\u306b\u95a2\u3059\u308bMultivariate Genetic Model\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u7537\u5973\u3068\u3082\u306b\u5168\u5f62\u8cea\u3092\u7d71\u4e00\u7684\u306b\u8aac\u660e\u3057\u3046\u308b\u30e2\u30c7\u30eb\u306f\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u904b\u52d5\u306e\u767a\u9054\u306b\u95a2\u3059\u308b2\u5f62\u8cea\u9593\u306e\u76f8\u95a2\u4fc2\u6570\u3092\u7b97\u51fa\u3057\u305f\u7d50\u679c\u3001\u4e73\u5150\u671f\u5f8c\u534a\u4ee5\u964d\u306b\u51fa\u73fe\u3059\u308b\u5f62\u8cea\u9593\u306b\u6bd4\u8f03\u7684\u5f37\u3044\u76f8\u95a2\u304c\u898b\u3089\u308c\u305f\u3002\u30e2\u30c7\u30eb\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u306e\u7d50\u679c\u3001\u7279\u306b\u5973\u5b50\u306e\u300c\u9996\u306e\u3059\u308f\u308a-\u306f\u3044\u306f\u3044\u300d\u300c\u9996\u306e\u3059\u308f\u308a-\u3064\u304b\u307e\u308a\u7acb\u3061\u300d\u300c\u9996\u306e\u3059\u308f\u308a-\u3072\u3068\u308a\u6b69\u304d\u300d\u300c\u306f\u3044\u306f\u3044-\u3072\u3068\u308a\u6b69\u304d\u300d\u3067\u3088\u3044\u9069\u5408\u3092\u793a\u3057\u305f\u3002//5.\u8003\u5bdf//\u3000\u884c\u52d5\u4e0a\u306e\u554f\u984c\u306b\u95a2\u3057\u3066\u306f\u5168\u822c\u7684\u306b\u76f8\u52a0\u7684\u907a\u4f1d\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u5927\u304d\u304b\u3063\u305f\u3002\u300c\u5bdd\u8a00\u300d\u300c\u591c\u8b66\u300d\u306a\u3069\u304c\u907a\u4f1d\u898f\u5b9a\u6027\u306e\u5f37\u3044\u5f62\u8cea\u3067\u3042\u308b\u4e8b\u304c\u5224\u660e\u3057\u305f\u3002\u300c\u591c\u5c3f\u300d\u300c\u5bdd\u307c\u3051\u300d\u3067\u306f\u907a\u4f1d\u8981\u56e0\u306b\u6027\u5dee\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u300c\u591c\u5c3f\u300d\u306b\u95a2\u3057\u3066\u306f\u7537\u5973\u3068\u3082\u306b\u5171\u6709\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u5f37\u304f\u3001\u305d\u306e\u6cbb\u7642\u306b\u3042\u305f\u3063\u3066\u306f\u74b0\u5883\u8981\u56e0\u306b\u8a34\u3048\u308b\u4e8b\u304c\u6709\u52b9\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u300c\u591c\u5c3f\u300d\u3092\u5e74\u9f62\u5225\u306b\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u5973\u5b50\u3067\u306f\u5e74\u9f62\u3068\u3068\u3082\u306b\u907a\u4f1d\u65e2\u5b9a\u6027\u304c\u5f37\u304f\u306a\u308b\u50be\u5411\u306b\u3042\u3063\u305f\u3002\u5973\u5b50\u306b\u304a\u3044\u30665\u6b73\u4ee5\u964d\u3067\u3082\u300c\u591c\u5c3f\u300d\u304c\u7d99\u7d9a\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u907a\u4f1d\u6027\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u304a\u308b\u3068\u601d\u308f\u308c\u305f\u3002\u300c\u5403\u97f3\u300d\u300c\u30c1\u30c3\u30af\u300d\u3067\u306f\u9069\u5408\u3059\u308b\u30e2\u30c7\u30eb\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u985e\u4f3c\u5ea6\u305d\u306e\u3082\u306e\u306fMZ\u304cDZ\u3088\u308a\u3082\u9ad8\u304f\u907a\u4f1d\u8981\u56e0\u306e\u95a2\u4e0e\u3092\u793a\u5506\u3057\u305f\u3002//\u3000Multivariate Genetic Model\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u7761\u7720\u6642\u306e\u884c\u52d5\u4e0a\u306e\u554f\u984c\u3068\u306a\u308b\u5f62\u8cea\u306b\u306f\u7279\u7570\u7684\u306b\u50cd\u304f\u8981\u56e0\u3068\u3068\u3082\u306b\u8907\u6570\u306e\u5f62\u8cea\u306b\u5171\u901a\u306b\u95a2\u4e0e\u3059\u308b\u8981\u56e0\u304c\u5b58\u5728\u3059\u308b\u4e8b\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u3053\u308c\u306f\u3001\u5404\u7a2e\u306e\u75be\u60a3\u306e\u4f75\u767a\u3092\u8003\u3048\u308b\u969b\u306b\u8003\u616e\u3059\u3079\u304d\u4e8b\u5b9f\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002//\u3000\u904b\u52d5\u306e\u767a\u9054\u306b\u95a2\u3057\u3066\u306f\u5404\u9805\u76ee\u3068\u3082\u306b\u5171\u901a\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u304c\u5927\u304d\u3044\u4e8b\u304c\u5224\u660e\u3057\u305f\u30022\u3064\u306e\u5f62\u8cea\u9593\u3067\u306f\u30e2\u30c7\u30eb\u304c\u9069\u5408\u3057\u305f\u3082\u306e\u306e\u3001\u5168\u4f53\u3092\u8aac\u660e\u3059\u308b\u30e2\u30c7\u30eb\u306f\u5f97\u3089\u308c\u305a\u3055\u3089\u306a\u308b\u691c\u8a0e\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002//\u3000\u3053\u3068\u3070\u306e\u767a\u9054\u306b\u95a2\u3057\u3066\u306f\u3001\u89e3\u6790\u9805\u76ee\u304c1\u3064\u3067\u3042\u308b\u305f\u3081\u65ad\u5b9a\u7684\u306a\u4e8b\u306f\u3044\u3048\u306a\u3044\u304c\u3001\u7537\u5b50\u306b\u7279\u7570\u7684\u306b\u50cd\u304f\u907a\u4f1d\u8981\u56e0(A\u2019m)\u306e\u5b58\u5728\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u3053\u3068\u3070\u306e\u767a\u9054\u306e\u6027\u5dee\u3092\u8003\u3048\u308b\u969b\u306b\u8003\u616e\u3059\u3079\u304d\u70b9\u3067\u3042\u308b\u3068\u601d\u308f\u308c\u305f\u3002//\u3000\u4ee5\u4e0a\u306e\u7d50\u679c\u306f\u3001\u3053\u308c\u307e\u3067\u7d4c\u9a13\u7684\u306b\u8a18\u8ff0\u3055\u308c\u3066\u304d\u305f\u5c0f\u5150\u671f\u306e\u884c\u52d5\u4e0a\u306e\u554f\u984c\u3001\u904b\u52d5\u306e\u767a\u9054\u30fb\u3053\u3068\u3070\u306e\u767a\u9054\u306b\u95a2\u3059\u308b\u907a\u4f1d\u8981\u56e0/\u74b0\u5883\u8981\u56e0\u306e\u95a2\u4e0e\u3092\u7d71\u8a08\u5b66\u7684\u306b\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u4eca\u5f8c\u306f\u305d\u308c\u305e\u308c\u306e\u5177\u4f53\u7684\u306a\u8981\u56e0\u3068\u305d\u306e\u95a2\u4e0e\u306e\u7a0b\u5ea6\u3092\u63a2\u7d22\u3059\u308b\u4e8b\u306b\u306a\u308b\u3002","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7","attribute_value_mlt":[{"subitem_dissertationnumber":"\u4e59\u7b2c14322\u53f7"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"7394","nameIdentifierScheme":"WEKO"}],"names":[{"name":"\u30aa\u30aa\u30ad, 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