{"created":"2021-03-01T06:16:34.252835+00:00","id":36,"links":{},"metadata":{"_buckets":{"deposit":"42169676-9d99-49f3-9b56-7243c33e4b25"},"_deposit":{"id":"36","owners":[],"pid":{"revision_id":0,"type":"depid","value":"36"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000036","sets":["6:18:19","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1636","bibliographicPageStart":"1631","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Tetrahedron, asymmetry"}]}]},"item_2_description_13":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The resolution of racemic 3-(methylamino)-1-(2-thienyl)propan-1-ol (3), a new key intermediate for duloxetine (1), was studied.  The conditions were optimized for an industrial-scale resolution of 3 by using (S)-mandelic acid (4) as a resolving agent and 2-butanol containing two equimolar amounts of water as a solvent.  The (S)-3･(S)-4･H2O diastereomeric salt was crystallized to give pure (S)-3 with >99.9% ee after liberation of the amine.  Absolute configuration of liberated (-)-3 was determined as (S)-form by X-ray crystallography.","subitem_description_type":"Abstract"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"155","nameIdentifierScheme":"WEKO"}],"names":[{"name":"西郷, 和彦"}]}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/S0957-4166(03)00315-X","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/journal/09574166","subitem_relation_type_select":"URI"}}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1074621X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09574166","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saigo, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Rumiko"}],"nameIdentifiers":[{"nameIdentifier":"152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuzawa, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"154","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-30"}],"displaytype":"detail","filename":"1_Elsevier.pdf","filesize":[{"value":"106.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1_Elsevier.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/36/files/1_Elsevier.pdf"},"version_id":"4f27b14f-9658-4e5f-97f6-6219cb2ebbba"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid"}]},"item_type_id":"2","owner":"1","path":["11","19"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-01-10"},"publish_date":"2007-01-10","publish_status":"0","recid":"36","relation_version_is_last":true,"title":["Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:40:59.853867+00:00"}