{"created":"2021-03-01T06:20:43.915512+00:00","id":4076,"links":{},"metadata":{"_buckets":{"deposit":"5cd2bd3b-0557-4132-812b-d5694735a21f"},"_deposit":{"id":"4076","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4076"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00004076","sets":["125:126:347","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"成人期の疾患発症に胎生期の環境要因がエピゲノム変化を介して関与するとの学説Developmental Origins of Health and Disease(DOHaD)が国際的に注目されている。必須微量元素である亜鉛が胎生期に欠乏することにより、出生後の健康に影響をもたらすことから、亜鉛欠乏のエピジェネティックな影響について検討した。細胞内亜鉛の動態に関与が知られているメタロチオネイン(MT)焦点を当て解析した。その結果、胎生期低亜鉛環境により仔のMT2プロモーターでのエピゲノム変化、特にヒストンのアセチル化が亢進し、それが記憶として成熟後まで残り、カドミウム曝露によるMT2誘導増強を引き起こすことが示唆された。本研究の結果は、胎生期の微量元素欠乏がエピゲノム変化を引き起す初めての事例である。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第27030号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9396","nameIdentifierScheme":"WEKO"}],"names":[{"name":"くりた, ひさか"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00004067","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Social Medicine, Graduate School of Medicine (医学系研究科社会医学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3640号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科社会医学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"栗田, 尚佳"}],"nameIdentifiers":[{"nameIdentifier":"9395","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h22_kurita.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h22_kurita.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/4076/files/h22_kurita.pdf"},"version_id":"570814e6-0914-47ca-936c-f07935067e99"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"胎生期低亜鉛環境が引き起こす仔におけるエピゲノム変化の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胎生期低亜鉛環境が引き起こす仔におけるエピゲノム変化の解析"}]},"item_type_id":"7","owner":"1","path":["280","347"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-08"},"publish_date":"2012-11-08","publish_status":"0","recid":"4076","relation_version_is_last":true,"title":["胎生期低亜鉛環境が引き起こす仔におけるエピゲノム変化の解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:45:50.460789+00:00"}