{"created":"2021-03-01T06:20:44.285994+00:00","id":4082,"links":{},"metadata":{"_buckets":{"deposit":"c0794bdb-fada-4fd7-a4f8-378ae5f5a770"},"_deposit":{"id":"4082","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4082"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00004082","sets":["125:358:359","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"系統的マイクロアレイ解析により、リガンド未知のGタンパク共役受容体であるGPR87が、肺扁平上皮癌などで発現亢進しているとの知見が得られた。そこで、GPR87ノックアウトマウスにジーンガン免疫を行った結果、6種類の抗GPR87モノクローナル抗体の作製に成功した。これらの抗体はすべてIgG1の抗GPR87モノクローナル抗体で、このうち、C0804を癌組織の免疫組織染色を行ったところ、扁平上皮癌及び移行上皮癌で癌細胞に陽性所見が認められた。C0804をRI標識化してMe180担癌モデルマウスに投与し、PETイメージングを行った結果、RI標識化抗体は癌部へ特異的に集積することが証明された。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第26971号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9408","nameIdentifierScheme":"WEKO"}],"names":[{"name":"にわ, しゅんすけ"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00004073","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Molecular Cell Biology, Graduate School of Medicine (医学系研究科分子細胞生物学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3581号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科分子細胞生物学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丹羽, 俊輔"}],"nameIdentifiers":[{"nameIdentifier":"9407","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h22_niwa.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h22_niwa.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/4082/files/h22_niwa.pdf"},"version_id":"469206c2-a71c-4b4f-ae59-baae4b76b305"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"抗GPR87モノクローナル抗体を用いた扁平上皮癌の診断・治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗GPR87モノクローナル抗体を用いた扁平上皮癌の診断・治療法の開発"}]},"item_type_id":"7","owner":"1","path":["280","359"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-08"},"publish_date":"2012-11-08","publish_status":"0","recid":"4082","relation_version_is_last":true,"title":["抗GPR87モノクローナル抗体を用いた扁平上皮癌の診断・治療法の開発"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:45:50.668045+00:00"}