{"created":"2021-03-01T06:20:44.410320+00:00","id":4084,"links":{},"metadata":{"_buckets":{"deposit":"769af133-02d6-4c4d-9d45-432245cf7538"},"_deposit":{"id":"4084","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4084"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00004084","sets":["125:348:349","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"グリア細胞の細胞骨格であるグリア線維性酸性タンパク（GFAP）は、耳介軟骨由来の軟骨細胞にも発現している。われわれは再生軟骨の製造においてGFAPを耳介軟骨細胞の基質産生指標として使用している。本研究では、経験的に評価指標として使用されているGFAPの、軟骨細胞での意義と役割を明らかにし、軟骨再生医療の品質管理に有用な情報を提供することを目的として、ヒトやマウス由来の培養軟骨細胞におけるGFAPの機能を評価した。その結果、GFAPは細胞の生存や機能発現に必須な核の形態や機能の保持に重要な役割を担っていた。したがって、GFAPが基質産生の指標として使用されることは合理的なことであると考えられた。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第27100号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9412","nameIdentifierScheme":"WEKO"}],"names":[{"name":"かなざわ, さんしろう"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00004075","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Surgical Sciences, Graduate School of Medicine (医学系研究科外科学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3710号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科外科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金澤, 三四朗"}],"nameIdentifiers":[{"nameIdentifier":"9411","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h22_kanazawa.pdf","filesize":[{"value":"389.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h22_kanazawa.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/4084/files/h22_kanazawa.pdf"},"version_id":"9a6b4df6-4661-45fa-b038-85d93926d241"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h22_kanazawa_fig.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h22_kanazawa_fig.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/4084/files/h22_kanazawa_fig.pdf"},"version_id":"bb284b98-c69a-4a2a-8e97-dfb53a27743d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"軟骨再生医療の細胞源となる弾性(耳介)軟骨細胞におけるGFAPの発現と生物学的機能に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"軟骨再生医療の細胞源となる弾性(耳介)軟骨細胞におけるGFAPの発現と生物学的機能に関する研究"}]},"item_type_id":"7","owner":"1","path":["280","349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-08"},"publish_date":"2012-11-08","publish_status":"0","recid":"4084","relation_version_is_last":true,"title":["軟骨再生医療の細胞源となる弾性(耳介)軟骨細胞におけるGFAPの発現と生物学的機能に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:45:50.115718+00:00"}