{"created":"2021-03-01T06:20:44.533874+00:00","id":4086,"links":{},"metadata":{"_buckets":{"deposit":"efeb43c9-f21a-4bda-8c0f-f838f34336eb"},"_deposit":{"id":"4086","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4086"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00004086","sets":["125:197:357","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多様性の高いゲノムを有するエイズウイルスの中で比較的保存性が高いゲノム領域にコードされるGagカプシドタンパク(CA)の構造上の制約を知ることは、ワクチン抗原デザインや抗HIV薬開発に有用である。私は細胞傷害性Tリンパ球の認識に影響するCAの1アミノ酸置換を有する変異体の解析を行い、CAのN末端ドメイン内のある1アミノ酸とC末端ドメイン内の1アミノ酸の相互作用がウイルス複製に重要であることをin vitroおよびin vivoの両視点から明らかにした。本研究は、CAドメイン間の機能的相互作用のための構造上の制約を提示するものである。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第26983号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9416","nameIdentifierScheme":"WEKO"}],"names":[{"name":"いながき, なつこ"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00004077","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Pathology, Immunology and Microbiology, Graduate School of Medicine (医学系研究科病因・病理学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3593号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科病因・病理学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲垣, 奈都子"}],"nameIdentifiers":[{"nameIdentifier":"9415","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h22_inagaki.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h22_inagaki.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/4086/files/h22_inagaki.pdf"},"version_id":"c6f68cc5-2204-4e96-9873-2f55163f58c4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"サル免疫不全ウイルス・カプシド蛋白の分子間N-Cドメインの機能的相互作用に重要なアミノ酸配列に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サル免疫不全ウイルス・カプシド蛋白の分子間N-Cドメインの機能的相互作用に重要なアミノ酸配列に関する研究"}]},"item_type_id":"7","owner":"1","path":["280","357"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-08"},"publish_date":"2012-11-08","publish_status":"0","recid":"4086","relation_version_is_last":true,"title":["サル免疫不全ウイルス・カプシド蛋白の分子間N-Cドメインの機能的相互作用に重要なアミノ酸配列に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:45:50.716475+00:00"}