{"created":"2021-03-01T06:20:44.655625+00:00","id":4088,"links":{},"metadata":{"_buckets":{"deposit":"a82f2a07-e850-413c-bf34-c167da0e8af3"},"_deposit":{"id":"4088","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4088"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00004088","sets":["125:355:356","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-24","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-03-24"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"線維芽細胞増殖因子(fibroblast growth factor:FGF)23は、骨細胞で産生され主に腎臓に作用し、リン・ビタミンD代謝を調節するホルモンである。In vitroの発現実験では、一部のFGF23蛋白はプロセッシングを受け、リン利尿作用を有さないフラグメントに分解されることが知られている。一方、FGF23蛋白の体内での存在様式やその作用には不明な点が残されている。私は、FGF23が高値となる疾患群において体内でのFGF23蛋白の存在様式を検討し、生体内においてもFGF23フラグメントが存在していることを明らかにした。また過剰量のフラグメントが、FGF23蛋白作用を抑制する可能性を明らかにした。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第27055号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9420","nameIdentifierScheme":"WEKO"}],"names":[{"name":"しみず, ゆういちろう"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00004079","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Internal Medicine, Graduate School of Medicine (医学系研究科内科学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3665号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科内科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 祐一郎"}],"nameIdentifiers":[{"nameIdentifier":"9419","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h22_shimizu.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h22_shimizu.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/4088/files/h22_shimizu.pdf"},"version_id":"19c102e9-d39a-476d-afb1-4a64d96b07bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"線維芽細胞増殖因子(fibroblast growth factor)23蛋白の生体内での存在様式とその作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"線維芽細胞増殖因子(fibroblast growth factor)23蛋白の生体内での存在様式とその作用"}]},"item_type_id":"7","owner":"1","path":["280","356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-11-08"},"publish_date":"2012-11-08","publish_status":"0","recid":"4088","relation_version_is_last":true,"title":["線維芽細胞増殖因子(fibroblast growth factor)23蛋白の生体内での存在様式とその作用"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:45:50.894852+00:00"}