{"created":"2021-03-01T06:22:10.293901+00:00","id":5474,"links":{},"metadata":{"_buckets":{"deposit":"5baf0428-8ced-4b32-a508-748bdb976184"},"_deposit":{"id":"5474","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5474"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005474","sets":["125:423:424","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"定型発達者の中にも閾値下の自閉症的行動特性（ALTs）が見られ、自閉症スペクトラム障害（ASDs）と遺伝的に重複しているため、ALTsの検討はASDsを解明する糸口として重要である。本研究ではASDsのアジア人でのリスクアレルであるオキシトシンレセプター遺伝子（OXTR）rs2254298AとALTsを結ぶ中間表現型を同定するために局所灰白質体積や解剖的カップリングを指標として調べた。その結果男性でALTsの社会性ドメインの自閉症傾向が強いほど右島灰白質体積が小さく、右島と腹側前部帯状回の解剖的カップリングが減弱している事、OXTR rs2254298Aを多くもつほど右島灰白質体積が小さい事が示せた。よって右島灰白質体積はALTsとOXTR rs2254298Aを結ぶ男女二形性をもつ中間表現型候補である事が示せた。","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005465","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Neuroscience , Graduate School of Medicine(医学系研究科脳神経医学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科脳神経医学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齋藤, 有希"}],"nameIdentifiers":[{"nameIdentifier":"11417","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"H24_4053_saito.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4053_saito.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5474/files/H24_4053_saito.pdf"},"version_id":"667d458b-056f-4866-9064-158416e23e9a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"自閉症的行動特性とオキシトシン受容体遺伝子多型を結ぶ中間表現型としての脳形態指標とその性差に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症的行動特性とオキシトシン受容体遺伝子多型を結ぶ中間表現型としての脳形態指標とその性差に関する研究"}]},"item_type_id":"7","owner":"1","path":["280","424"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"5474","relation_version_is_last":true,"title":["自閉症的行動特性とオキシトシン受容体遺伝子多型を結ぶ中間表現型としての脳形態指標とその性差に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:03.236024+00:00"}