{"created":"2021-03-01T06:22:10.534973+00:00","id":5478,"links":{},"metadata":{"_buckets":{"deposit":"96608173-94b6-49c3-abc5-abf9dda321cb"},"_deposit":{"id":"5478","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5478"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005478","sets":["125:355:356","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Activation-induced cytidine deaminase(AID)は、活性化B細胞における体細胞突然変異(SHM)や、クラススイッチ組換え(CSR)に必須の酵素である。AIDの過剰発現が、異常な体細胞突然変異や染色体転座を惹起し、腫瘍形成へ関与する。メシル酸イマチニブ(IM)は、慢性骨髄性白血病の原因遺伝子であるBCR-ABL融合遺伝子の産物に対する分子標的薬である。IM投与中に免疫グロブリン値の低下をしばしば認めるが、その機序は明らかではない。今回私は、IMがAIDの抑制を介したCSR抑制作用を有し、AID発現調節因子の中でも特にE2Aが重要な役割を果たしていることを示した。","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005469","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Internal Medicine, Graduate School of Medicine(医学系研究科内科学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科内科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川俣, 豊隆"}],"nameIdentifiers":[{"nameIdentifier":"11421","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"H24_4081_kawamata.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4081_kawamata.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5478/files/H24_4081_kawamata.pdf"},"version_id":"4a2b442a-6116-44ed-b2f6-2957292bde61"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Activation-induced cytidine deaminase(AID)を介するメシル酸イマチニブのB細胞分化抑制作用の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation-induced cytidine deaminase(AID)を介するメシル酸イマチニブのB細胞分化抑制作用の解析"}]},"item_type_id":"7","owner":"1","path":["280","356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"5478","relation_version_is_last":true,"title":["Activation-induced cytidine deaminase(AID)を介するメシル酸イマチニブのB細胞分化抑制作用の解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T04:49:50.875674+00:00"}