{"created":"2021-03-01T06:22:10.595843+00:00","id":5479,"links":{},"metadata":{"_buckets":{"deposit":"b340ce32-07be-493f-8b34-89251329d9c0"},"_deposit":{"id":"5479","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5479"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005479","sets":["125:348:349","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The role of Erk2 signaling in central nervous system"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多発性硬化症などの脱髄疾患は、炎症、脱髄、グリオーシス、軸索変性を特徴とする。脱髄巣ではオリゴデンドロサイト細胞死と炎症が観察され、炎症の制御は脱髄疾患治療の重要なターゲットであり、これまでに生化学的、組織学的な研究がおこなわれてきた。今回我々は、 マウス脱髄疾患モデルを用い、細胞内シグナルErk2 が中枢神経炎症制御において果たす役割を解析した。カプリゾンの経口投与による可逆的な脱髄モデルを選択し、Nestin-Cre によって神経幹細胞由来の細胞でErk2 発現が欠失したコンディショナルノックアウトマウスを用い、行動学的、生化学的、組織学的に解析を行った。その結果、Erk2 欠損マウスではカプリゾン投与による炎症性脱髄病態が軽減しており、そのメカニズムとしてアストロサイトでのErk2 活性化が炎症反応の増大に寄与していると考えられた。今後、炎症を伴う中枢神経疾患に対する分子標的治療のターゲットとして、アストロサイトのErk2 活性化に係るシグナルは有望な候補の一つであると考えられる。","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005470","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Surgical Sciences, Graduate School of Medicine(医学系研究科外科学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科外科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡崎, 廉太郎"}],"nameIdentifiers":[{"nameIdentifier":"11422","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"H24_4128_okazaki.pdf","filesize":[{"value":"58.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4128_okazaki.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5479/files/H24_4128_okazaki.pdf"},"version_id":"580340aa-3fb0-4ca1-bb10-874f920fec29"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"中枢神経におけるErk2シグナルの役割に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢神経におけるErk2シグナルの役割に関する研究"}]},"item_type_id":"7","owner":"1","path":["280","349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"5479","relation_version_is_last":true,"title":["中枢神経におけるErk2シグナルの役割に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:04.674883+00:00"}