{"created":"2021-03-01T06:22:10.657794+00:00","id":5480,"links":{},"metadata":{"_buckets":{"deposit":"bc47ed4d-d34c-441b-8377-22092512c0d2"},"_deposit":{"id":"5480","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5480"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005480","sets":["125:348:349","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Antitumor effect of temsirolimus, a derivative of rapamycin, against colorectal cancer : in vitro and in vivo studies"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、mammalian target of rapamycin（mTOR）を阻害する分子標的薬であるtemsirolimus（TEM）に着目し、まず、本薬剤単剤での大腸癌に及ぼす影響について検討を行った。TEMはin vitroにおいて、大腸癌の細胞周期をG1期で停止させることにより細胞増殖を濃度依存的に抑制し、さらには血管新生に関与するHIF-1αとVEGFの発現を抑制した。in vivoにおいても血管新生抑制作用が認められ、腫瘍増殖が抑制された。一方で、TEM作用に対する防御機構として大腸癌細胞がオートファジーを誘導することが確認されたため、オートファジー阻害薬であるクロロキン（CQ）をTEMに併用したところ、in vitro およびin vivoにおいてアポトーシス誘導および腫瘍抑制効果が増強された。","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005471","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Surgical Sciences, Graduate School of Medicine(医学系研究科外科学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科外科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 学"}],"nameIdentifiers":[{"nameIdentifier":"11423","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"H24_4129_kaneko.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4129_kaneko.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5480/files/H24_4129_kaneko.pdf"},"version_id":"e5f4c778-7eef-48fa-bb5a-e06cd537798f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Temsirolimus（Rapamycin誘導体）の大腸癌に対する抗腫瘍効果の研究－in vitroおよびin vivo解析－","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Temsirolimus（Rapamycin誘導体）の大腸癌に対する抗腫瘍効果の研究－in vitroおよびin vivo解析－"}]},"item_type_id":"7","owner":"1","path":["280","349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"5480","relation_version_is_last":true,"title":["Temsirolimus（Rapamycin誘導体）の大腸癌に対する抗腫瘍効果の研究－in vitroおよびin vivo解析－"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:04.700708+00:00"}