{"created":"2021-03-01T06:22:10.718338+00:00","id":5481,"links":{},"metadata":{"_buckets":{"deposit":"e6262dfc-cc20-4c68-b4ff-6102acdb69dd"},"_deposit":{"id":"5481","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5481"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005481","sets":["125:348:349","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Charges in function and expression of T-type and N-type calcium channels in the rat after bladden outlet obstruction"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"下部尿路閉塞(BOO)ラットを用いて、BOOに伴う膀胱機能障害おけるT型カルシウムイオンチャンネル(T-Ca)およびN型カルシウムイオンチャンネル(N-Ca)の関与を検討した。BOOラット膀胱では、T-CaおよびN-Caの発現が増加していた。BOOラットにおいて、T-Ca阻害薬の静脈内投与は、膀胱容量を増大し、N-Ca阻害薬の静脈内投与はnon-voiding contractions (NVCs)の数を減少した。N-Ca阻害薬は、BOOラット膀胱の経壁電気刺激に対する収縮反応を抑制した。BOOラットにおいて、T-Caは排尿反射閾値の低下に、N-CaはNVCsの発生並びに神経原性膀胱収縮の促進に寄与する。","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005472","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Surgical Sciences, Graduate School of Medicine(医学系研究科外科学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科外科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊野, 信太郎"}],"nameIdentifiers":[{"nameIdentifier":"11424","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"H24_4131_kumano.pdf","filesize":[{"value":"5.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4131_kumano.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5481/files/H24_4131_kumano.pdf"},"version_id":"cc3f75cf-432d-4967-9a98-2c0c5e5f1fe8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"膀胱におけるT型およびN型カルシウムチャンネルの役割 : 下部尿路閉塞ラットを用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膀胱におけるT型およびN型カルシウムチャンネルの役割 : 下部尿路閉塞ラットを用いた検討"}]},"item_type_id":"7","owner":"1","path":["280","349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"5481","relation_version_is_last":true,"title":["膀胱におけるT型およびN型カルシウムチャンネルの役割 : 下部尿路閉塞ラットを用いた検討"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:04.727227+00:00"}