{"created":"2021-03-01T06:22:10.839949+00:00","id":5483,"links":{},"metadata":{"_buckets":{"deposit":"f70e7f1c-e5a1-4a76-a92e-97fe1a591514"},"_deposit":{"id":"5483","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5483"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005483","sets":["125:157:360","9:233:280"]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(保健学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ブタ回虫は生活環において、エネルギー代謝系を好気的から嫌気的に転換し環境の変化に適応している。嫌気的代謝系におけるNADH-フマル酸還元系は宿主哺乳類には存在しないミトコンドリア呼吸鎖であり、格好の薬剤標的と考えられている。また、ミトコンドリア呼吸鎖の変動のステージ毎における詳細な情報は、現在、様々な分野で注目されている低酸素適応機構を理解する上でも重要である。本研究では環境の酸素分圧が劇的に変化するLL3、ヤングアダルト (YA)、成虫のミトコンドリア呼吸鎖の生化学的解析を行なった。YAは、成虫と生息域、形態は同様であるがミトコンドリア呼吸鎖の変動は完了していないことが明らかになった。さらに、ブタ回虫複合体IIの特異的な阻害剤として、Flutolanil誘導体の構造活性相関解析を行ない、選択性が20,000倍まで向上した化合物を得ることができた。","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005474","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Health Science(保健学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of International Health, Graduate School of Medicine(医学系研究科国際保健学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科国際保健学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大森, 惇子"}],"nameIdentifiers":[{"nameIdentifier":"11427","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"H24_4155_omori.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4155_omori.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5483/files/H24_4155_omori.pdf"},"version_id":"ac1de3ab-47c7-4ff1-9d2d-079d9d8acd03"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"薬剤標的としてのブタ回虫ミトコンドリア呼吸鎖の生化学的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬剤標的としてのブタ回虫ミトコンドリア呼吸鎖の生化学的解析"}]},"item_type_id":"7","owner":"1","path":["280","360"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"5483","relation_version_is_last":true,"title":["薬剤標的としてのブタ回虫ミトコンドリア呼吸鎖の生化学的解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:04.783398+00:00"}