{"created":"2021-03-01T06:22:16.878380+00:00","id":5581,"links":{},"metadata":{"_buckets":{"deposit":"bda4bd30-7b17-406e-a55d-b24d3655539b"},"_deposit":{"id":"5581","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5581"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005581","sets":["125:358:359","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The novel roles for apoptpsis inhibitor of macrophage (AIM) in metabolic syndrome"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-22","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2012-03-22"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"メタボリックシンドロームの病態形成を理解する上で、脂肪組織に浸潤・蓄積するマクロファージの重要性が広く認識されている。私は、マクロファージが産生・分泌するAIM(apoptosis inhibitor of macrophage)が肥大化した脂肪細胞に対して脂肪融解(Lipolysis)を強力に誘導することを見出した。さらに、AIMによるLipolysisが、メタボリックシンドローム病態形成に必須である脂肪組織へのマクロファージ浸潤に極めて重要な役割を果たすことを明らかとした。これらの結果は、AIMを標的としたメタボリックシンドローム新規治療法の開発を期待させるものである。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第28131号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11620","nameIdentifierScheme":"WEKO"}],"names":[{"name":"くろかわ, じゅん"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005572","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Molecular Cell Biology, Graduate School of Medicine (医学系研究科分子細胞生物学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3790号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科分子細胞生物学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黒川, 淳"}],"nameIdentifiers":[{"nameIdentifier":"11619","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h23_kurokawa.pdf","filesize":[{"value":"5.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h23_kurokawa.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5581/files/h23_kurokawa.pdf"},"version_id":"ebdd9742-e685-4514-bb4f-4a58b9bfbe4d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"アポトーシス抑制因子AIMを基盤としたメタボリックシンドローム病態形成機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アポトーシス抑制因子AIMを基盤としたメタボリックシンドローム病態形成機構の解明"}]},"item_type_id":"7","owner":"1","path":["280","359"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-24"},"publish_date":"2014-02-24","publish_status":"0","recid":"5581","relation_version_is_last":true,"title":["アポトーシス抑制因子AIMを基盤としたメタボリックシンドローム病態形成機構の解明"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:09.234846+00:00"}