{"created":"2021-03-01T06:22:18.351399+00:00","id":5605,"links":{},"metadata":{"_buckets":{"deposit":"0a591643-2f9c-4cc8-94f9-590a7d1e3762"},"_deposit":{"id":"5605","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5605"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005605","sets":["110:267:345","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"なぜ感染で死ぬのか?感染の集団生物学の「実験+数理」解析系の創出"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-22","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2012-03-22"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(生命科学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Why do some organisms succumb and die easily when infected? Microbial infection often leads to expression of virulence and host death when symbiosis seems more beneficial for the infecting microbe's maintenance. Previously proposed explanations have focused on the pathogen's side. In this work, I tested a hypothesis focused on the host strategy. If a member of a host population dies immediately upon infection with a pathogen, thereby ending its reproduction, then its death could protect the host population from secondary and further infections. I tested this \"Suicidal Defense Against Infection\" (SDAI) hypothesis by developing an experimental infection system that involves a huge number of bacterial cells as host and their virus as pathogen and is linked to mathematical modeling. I prepared two host strains, one with the SDAI strategy (type A) and the other without (type S), mixed them at varying ratios, challenged them with the pathogen and monitored any change in the ratio during infection. I used two conditions for infection: standing solid agar providing spatial structure, thereby ensuring that individuals preferentially interact with their neighbors, and well-mixed liquid lacking spatial structure. I found that the SDAI strategy has great advantage in the presence of spatial structure: Pathogen increase was accompanied by a large increase in the A:S ratio. In contrast, there was a decrease in the A:S ratio in the absence of spatial structure. My simulation reproduced the essential features of the experimental results. These results provide a new perspective for understanding host-pathogen interaction.","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第28421号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11668","nameIdentifierScheme":"WEKO"}],"names":[{"name":"福世, 真樹"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005596","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Integrated Biosciences (生命科学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Medical Genome Sciences, Graduate School of Frontier Sciences (新領域創成科学研究科メディカルゲノム専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博創域第780号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院新領域創成科学研究科生命科学研究系メディカルゲノム専攻"},{"subitem_text_value":"Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukuyo, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"11667","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"K-03561.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"K-03561.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5605/files/K-03561.pdf"},"version_id":"aeb830c6-ed2f-4dac-b303-af9765a343b9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"感染","subitem_subject_scheme":"Other"},{"subitem_subject":"毒性","subitem_subject_scheme":"Other"},{"subitem_subject":"利他行動","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Success of a suicidal defense strategy against infection in a structured habitat","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Success of a suicidal defense strategy against infection in a structured habitat"}]},"item_type_id":"7","owner":"1","path":["280","345"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-24"},"publish_date":"2014-02-24","publish_status":"0","recid":"5605","relation_version_is_last":true,"title":["Success of a suicidal defense strategy against infection in a structured habitat"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:46:59.343847+00:00"}