{"created":"2021-03-01T06:22:18.820690+00:00","id":5612,"links":{},"metadata":{"_buckets":{"deposit":"01c7251a-2c7d-496a-b2a6-0ce85ed9a9b2"},"_deposit":{"id":"5612","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5612"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00005612","sets":["125:355:356","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A novel thymic pathway of autoreactive T cells in the regulation of autoimmunity"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-22","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2012-03-22"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膠原病では全身性自己免疫が病因に関わっており、自己反応性T細胞の制御機構の理解は病態解明や治療に重要である。本研究は自己反応性T細胞産生マウスを解析し、新たな自己反応性制御機構を検討した。その結果、既知の細胞除去と制御性T細胞への分化以外に、自己反応性T細胞が胸腺でanergicなIL21産生follicular helper T細胞(Tfh細胞)に分化する新たな経路の存在が判明した。本細胞は従来のTfh細胞と比べ、自己抗原認識、CXCR5陰性、胸腺分化の点が異なるが、多くの表面分子や転写因子は共通することから新規のnatural Tfh細胞と名付け、野生型マウスやヒトでの存在も確認した。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_26":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第28200号"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11682","nameIdentifierScheme":"WEKO"}],"names":[{"name":"あやべ(あかひら), りさ"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005603","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_subject_13":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Internal Medicine, Graduate School of Medicine (医学系研究科内科学専攻)"}]},"item_7_text_27":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_value":"博医第3859号"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学大学院医学系研究科内科学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"綾部(赤平), 理紗"}],"nameIdentifiers":[{"nameIdentifier":"11681","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"h23_ayabe_akahira.pdf","filesize":[{"value":"3.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"h23_ayabe_akahira.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5612/files/h23_ayabe_akahira.pdf"},"version_id":"3fa15c64-65d1-4fc2-a2f8-fe611b417659"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"全身性自己免疫制御における自己反応性T細胞の新たな分化経路の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性自己免疫制御における自己反応性T細胞の新たな分化経路の解明"}]},"item_type_id":"7","owner":"1","path":["280","356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-24"},"publish_date":"2014-02-24","publish_status":"0","recid":"5612","relation_version_is_last":true,"title":["全身性自己免疫制御における自己反応性T細胞の新たな分化経路の解明"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:47:11.775978+00:00"}