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sense various environmental stimuli and process the sensory information by the neural circuits to generate appropriate behavior in response to the stimuli. The model organism C. elegans detects NaCl by ASE gustatory neurons and shows attraction to NaCl. It has been shown that the attraction to NaCl is generated by two behavioral strategies called pirouette and weathervane strategies and that ASE sensory neurons and their downstream interneurons AIZ are required for both of these behavioral responses. However, the rest of the neural circuits underlying these behavioral mechanisms remain largely unknown. Here I observed the behavioral responses of animals with candidate neurons killed. AIA and AVA interneurons and SMD motor neurons are responsible only for the pirouette response, whereas AIY interneurons are required only for the weathervane response. Moreover, AIB interneurons and SMB head motor neurons are responsible for both behavioral responses. These results suggest the existence of partially distinct neural circuits regulating the two behavioral strategies for attraction to NaCl. Although animals show a specific response to each environmental stimulus as mentioned above, response to a particular stimulus can change depending on the strength of the stimulus. However, little is understood about the neural basis of this phenomenon. C. elegans avoids higher concentrations of odorants that are attractive at the lower concentrations. Here I analyzed this odor concentration-dependent change in olfactory preference. Behavioral analyses revealed that the odor concentration-dependent behavior is primarily generated by the pirouette mechanism. Genetic analyses and lesion experiments showed that distinct combinations of sensory neurons function at different concentrations of the odorant; AWC and ASH sensory neurons have critical roles for attraction to or avoidance of the odorant, respectively. Calcium imaging showed that AWC neuron responds to only lower concentrations of the odorant, and their responses disappear at higher concentrations probably due to a suppression effect of synaptic transmission from other neurons. On the other hand, ASH neurons responded to only higher concentrations of odorant. Hence, these results suggest that the odor concentration information in C. elegans is primarily modulated at the sensory neuron level.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11712","nameIdentifierScheme":"WEKO"}],"names":[{"name":"\u5409\u7530, \u548c\u53f2"}]}]},"item_7_identifier_registration":{"attribute_name":"ID\u767b\u9332","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00005620","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"\u5b66\u4f4d","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"\u5b66\u4f4d\u5206\u91ce","attribute_value_mlt":[{"subitem_text_value":"Science(Rigaku)(\u7406\u5b66)"}]},"item_7_text_24":{"attribute_name":"\u7814\u7a76\u79d1\u30fb\u5c02\u653b","attribute_value_mlt":[{"subitem_text_value":"Department of Earth and Planetary Science, Graduate School of Science (\u7406\u5b66\u7cfb\u7814\u7a76\u79d1\u5730\u7403\u60d1\u661f\u79d1\u5b66\u5c02\u653b)"}]},"item_7_text_4":{"attribute_name":"\u8457\u8005\u6240\u5c5e","attribute_value_mlt":[{"subitem_text_value":"\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7cfb\u7814\u7a76\u79d1\u751f\u7269\u5316\u5b66\u5c02\u653b"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Kazushi"}],"nameIdentifiers":[{"nameIdentifier":"11711","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-01"}],"displaytype":"detail","filename":"Thesis_yoshidakazushi.pdf","filesize":[{"value":"7.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Thesis_yoshidakazushi.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/5629/files/Thesis_yoshidakazushi.pdf"},"version_id":"dfbff28e-5ed4-4658-84fc-fd079c210400"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Analysis of neural circuit mechanisms regulating chemical sensation in C. elegans","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Analysis of neural circuit mechanisms regulating chemical sensation in C. elegans"}]},"item_type_id":"7","owner":"1","path":["9/233/280","75/275/400"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2014-02-24"},"publish_date":"2014-02-24","publish_status":"0","recid":"5629","relation_version_is_last":true,"title":["Analysis of neural circuit mechanisms regulating chemical sensation in C. elegans"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T19:41:59.854625+00:00"}