{"created":"2021-03-01T06:17:12.611587+00:00","id":666,"links":{},"metadata":{"_buckets":{"deposit":"c471c2ce-2eeb-4975-935b-0696909135a3"},"_deposit":{"id":"666","owners":[],"pid":{"revision_id":0,"type":"depid","value":"666"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000666","sets":["30:31","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"343","bibliographicPageStart":"ra88","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Science signaling"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pentraxin 3 (PTX3), a member of the long pentraxin subfamily within the family of pentraxins, is a soluble pattern recognition molecule that functions in the innate immune system. Innate immunity affords the infected host protection against sepsis, a potentially life-threatening inflammatory response to infection. Extracellular histones are considered to be the main cause of septic death because of their cytotoxic effect on endothelial cells, which makes them a potential therapeutic target. We found that PTX3 interacted with histones to form coaggregates, which depended on polyvalent interactions and disorder in the secondary structure of PTX3. PTX3 exerted a protective effect, both in vitro and in vivo, against histone-mediated cytotoxicity toward endothelial cells. Additionally, the intraperitoneal administration of PTX3 reduced mortality in mouse models of sepsis. The amino-terminal domain of PTX3, which was required for coaggregation with histones, was sufficient to protect against cytotoxicity. Our results suggest that the host-protective effects of PTX3 in sepsis are a result of its coaggregation with histones rather than its ability to mediate pattern recognition. This long pentraxin–specific effect provides a potential basis for the treatment of sepsis directed at protecting cells from the toxic effects of extracellular histones.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「ペントラキシン３の敗血症への効果を発見」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"Host-protective effect of pentraxin 3 in sepsis\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1126/scisignal.2005522","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://stke.sciencemag.org/content/7/343/ra88.abstract","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 Authors."}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12315525","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1945-0877","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1937-9145","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo"},{"subitem_text_value":"Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo"},{"subitem_text_value":"Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences"},{"subitem_text_value":"Department of Pathology, Niigata University Medical and Dental Hospital"},{"subitem_text_value":"Laboratory for Vascular Biology, Research Center for Advanced Science and Technology, The University of Tokyo"},{"subitem_text_value":"Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital"},{"subitem_text_value":"Department of Cardiology, Juntendo University Nerima Hospital"},{"subitem_text_value":"Niigata College of Medical Technology"},{"subitem_text_value":"Perseus Proteomics Inc."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Daigo, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"2358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakakido, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"2359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohashi, Riuko"}],"nameIdentifiers":[{"nameIdentifier":"2360","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuda, Rie"}],"nameIdentifiers":[{"nameIdentifier":"2361","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsubara, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"2362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minami, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"2363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Naotaka"}],"nameIdentifiers":[{"nameIdentifier":"2364","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"2365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jiang, Shuying"}],"nameIdentifiers":[{"nameIdentifier":"2366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"2367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsumoto, Kouhei"}],"nameIdentifiers":[{"nameIdentifier":"2368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hamakubo, Takao"}],"nameIdentifiers":[{"nameIdentifier":"2369","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-30"}],"displaytype":"detail","filename":"Sci_Signal-7_343_ra88_author.pdf","filesize":[{"value":"675.8 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sepsis"}]},"item_type_id":"2","owner":"1","path":["31","11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-04"},"publish_date":"2015-02-04","publish_status":"0","recid":"666","relation_version_is_last":true,"title":["Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-19T03:41:41.204277+00:00"}