{"created":"2021-03-01T06:17:13.717304+00:00","id":684,"links":{},"metadata":{"_buckets":{"deposit":"cefc3bab-0ab4-40ba-b3e9-12074c9fc23a"},"_deposit":{"id":"684","owners":[],"pid":{"revision_id":0,"type":"depid","value":"684"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000684","sets":["125:163:164","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-11-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5426","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The strength of the DNA damage checkpoint critically influences cell fate, yet the mechanisms behind the fine tuning of checkpoint strength during the DNA damage response (DDR) are poorly understood. Here we show that ​Rad54B—a SNF2 helicase-like DNA-repair protein—limits the strength of both the G1/S and G2/M checkpoints. We find that ​Rad54B functions as a scaffold for ​p53 degradation via its direct interaction with the ​MDM2–​MDMX ubiquitin–ligase complex. During the early phases of the DDR, ​Rad54B is upregulated, thereby maintaining low checkpoint strength and facilitating cell cycle progression. Once the ​p53-mediated checkpoint is established, ​Rad54B is downregulated, and high checkpoint strength is maintained. Constitutive upregulation of ​Rad54B activity, which is frequently observed in tumours, promotes genomic instability because of checkpoint override. Thus, the scaffolding function of ​Rad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「がん発生の基盤となる仕組みを探る」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"Discovery of a basic mechanism of cancer development\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/ncomms6426","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/ncomms/2014/141111/ncomms6426/abs/ncomms6426.html","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (C) 2014, Rights Managed by Nature Publishing Group"}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo"},{"subitem_text_value":"Department of Radiological Technology, Faculty of Medical Technology, Teikyo University"},{"subitem_text_value":"Isotope Science Center, The University of Tokyo"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasuhara, Takaaki"}],"nameIdentifiers":[{"nameIdentifier":"2472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takahiko"}],"nameIdentifiers":[{"nameIdentifier":"2473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsura, Mari"}],"nameIdentifiers":[{"nameIdentifier":"2474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyagawa, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"2475","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-30"}],"displaytype":"detail","filename":"ncomms6426_author_version.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ncomms6426_author_version.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/684/files/ncomms6426_author_version.pdf"},"version_id":"e7716cfc-4e93-45bd-af7e-dc62fce1ee70"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength"}]},"item_type_id":"2","owner":"1","path":["11","164"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-13"},"publish_date":"2015-05-13","publish_status":"0","recid":"684","relation_version_is_last":true,"title":["Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-19T03:41:40.210419+00:00"}