{"created":"2021-03-01T06:17:14.696503+00:00","id":700,"links":{},"metadata":{"_buckets":{"deposit":"417798be-58b7-4cef-8eb4-676a120fe12f"},"_deposit":{"id":"700","owners":[],"pid":{"revision_id":0,"type":"depid","value":"700"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000700","sets":["20:179:180","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"388","bibliographicPageStart":"ra78","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Science signaling"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Viral infection activates host defense mechanisms, including the production of type I interferon (IFN) and the apoptosis of infected cells. We investigated whether these two antiviral responses were differentially regulated in infected cells. We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal–regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-β (IFNB) and apoptotic cell death. In contrast, we found that the MAPKKK ASK2, a modulator of ASK1 signaling, was essential for ASK1-dependent apoptosis, but not for inducing IFNB expression. Furthermore, genetic deletion of either ASK1 or ASK2 in mice promoted the replication of influenza A virus in the lung. These results indicated that ASK1 and ASK2 are components of the antiviral defense mechanism and suggested that ASK2 acts as a key modulator that promotes apoptosis rather than the type I IFN response. Because ASK2 is selectively present in epithelium-rich tissues, such as the lung, ASK2-dependent apoptosis may contribute to an antiviral defense in tissues with a rapid repair rate in which cells could be readily replaced.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「生きるべきか死ぬべきか」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/to-be-or-not-to-be-that-is-the-question.html","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"To be, or not to be: That is the question\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/to-be-or-not-to-be-that-is-the-question.html","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1126/scisignal.aab1883","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/to-be-or-not-to-be-that-is-the-question.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/to-be-or-not-to-be-that-is-the-question.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://stke.sciencemag.org/content/8/388/ra78.abstract","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015 Authors."}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12315525","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19450877","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"19379145","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Laboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo"},{"subitem_text_value":"Division of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University"},{"subitem_text_value":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo"},{"subitem_text_value":"Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)"},{"subitem_text_value":"Department of Molecular Immunology and Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo"},{"subitem_text_value":"Max Planck-The University of Tokyo Center for Integrative Inflammology"},{"subitem_text_value":"Department of Virology 3, National Institute of Infectious Diseases"},{"subitem_text_value":"Medical Mycology Research Center, Chiba University"},{"subitem_text_value":"Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University"},{"subitem_text_value":"Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo"},{"subitem_text_value":"ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency"},{"subitem_text_value":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison"},{"subitem_text_value":"Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okazaki, Tomohiko"}],"nameIdentifiers":[{"nameIdentifier":"2586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"2587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, Kohsuke"}],"nameIdentifiers":[{"nameIdentifier":"2588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwatsuki-Horimoto, Kiyoko"}],"nameIdentifiers":[{"nameIdentifier":"2589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiso, Maki"}],"nameIdentifiers":[{"nameIdentifier":"2590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyagishi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"2591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanai, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"2592","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"2593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneyama, Mitsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"2594","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"2595","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, Tadatsugu"}],"nameIdentifiers":[{"nameIdentifier":"2596","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawaoka, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"2597","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichijo, Hidenori"}],"nameIdentifiers":[{"nameIdentifier":"2598","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gotoh, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"2599","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-30"}],"displaytype":"detail","filename":"scisignal.aab1883.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"scisignal.aab1883.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/700/files/scisignal.aab1883.pdf"},"version_id":"9cc8bcee-0f22-4009-b704-3f467eb0a458"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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