{"created":"2021-03-01T06:17:15.308906+00:00","id":710,"links":{},"metadata":{"_buckets":{"deposit":"f3ce62af-0bed-4bd1-aa47-50474319ee7c"},"_deposit":{"id":"710","owners":[],"pid":{"revision_id":0,"type":"depid","value":"710"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000710","sets":["27:183:184","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6780","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin-binding protein. Nedd4 recruits IRS-2 to the membrane, probably through promoting Epsin1 binding, and enhances IGF-I receptor-induced IRS-2 tyrosine phosphorylation. In thyroid FRTL-5 cells, activation of the cyclic AMP pathway increases the association of Nedd4 with IRS-2, thereby enhancing IRS-2-mediated signalling and cell proliferation induced by IGF-I. The Nedd4 and IRS-2 association is also required for maximal activation of IGF-I signalling and cell proliferation in prostate cancer PC-3 cells. Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 in vivo. We conclude that Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「動物の成長や細胞の増殖の新しい調節機構を発見」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"Novel regulatory mechanisms of animal growth and cell proliferation\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/ncomms7780","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/ncomms/2015/150416/ncomms7780/abs/ncomms7780.html","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015, Rights Managed by Nature Publishing Group"}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The University of Tokyo"},{"subitem_text_value":"Department of Medical Science, Graduate School of Medicine, Hiroshima University"},{"subitem_text_value":"Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science"},{"subitem_text_value":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China"},{"subitem_text_value":"Department of Molecular, Cellular and Developmental Biology, University of Michigan"},{"subitem_text_value":"Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukushima, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"2635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshihara, Hidehito"}],"nameIdentifiers":[{"nameIdentifier":"2636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuta, Haruka"}],"nameIdentifiers":[{"nameIdentifier":"2637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamei, Hiroyasu"}],"nameIdentifiers":[{"nameIdentifier":"2638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hakuno, Fumihiko"}],"nameIdentifiers":[{"nameIdentifier":"2639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Luan, Jing"}],"nameIdentifiers":[{"nameIdentifier":"2640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Duan, Cunming"}],"nameIdentifiers":[{"nameIdentifier":"2641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saeki, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"2642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Keiji"}],"nameIdentifiers":[{"nameIdentifier":"2643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iemura, Shun-Ichiro"}],"nameIdentifiers":[{"nameIdentifier":"2644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Natsume, Tohru"}],"nameIdentifiers":[{"nameIdentifier":"2645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chida, 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