{"created":"2021-03-01T06:17:16.554761+00:00","id":730,"links":{},"metadata":{"_buckets":{"deposit":"6ff3986f-4b34-4d6d-9c85-10c3e756b78e"},"_deposit":{"id":"730","owners":[],"pid":{"revision_id":0,"type":"depid","value":"730"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000730","sets":["125:199:200","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"8219","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten–eleven translocation (TET) proteins, which catalyse the oxidation of methylated cytosine (5-mC) to 5-hmC, TET2, is repressed by androgens in PCa. Androgen receptor (AR)-mediated induction of the miR-29 family, which targets TET2, are markedly enhanced in hormone refractory PCa (HRPC) and its high expression predicts poor outcome of PCa patients. Furthermore, decreased expression of miR-29b results in reduced tumour growth and increased TET2 expression in an animal model of HRPC. Interestingly, global 5-hmC modification regulated by miR-29b represses FOXA1 activity. A reduction in 5-hmC activates PCa-related key pathways such as mTOR and AR. Thus, DNA modification directly links the TET2-dependent epigenetic pathway regulated by AR to 5-hmC-mediated tumour progression.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「前立腺癌に対してホルモン療法が効きづらくなる理由」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"Why hormone therapy becomes ineffective against prostate cancer\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/ncomms9219","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/ncomms/2015/150925/ncomms9219/abs/ncomms9219.html","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015, Rights Managed by Nature Publishing Group"}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo"},{"subitem_text_value":"Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo"},{"subitem_text_value":"Department of Pathology, Graduate School of Medicine, Tohoku University"},{"subitem_text_value":"RIKEN Omics Science Center (OSC), RIKEN Yokohama Institute"},{"subitem_text_value":"RIKEN Preventive Medicine & Diagnosis Innovation Program"},{"subitem_text_value":"Department of Urology, Graduate School of Medicine, The University of Tokyo"},{"subitem_text_value":"Department of Urology, Nihon University School of Medicine"},{"subitem_text_value":"Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takayama, Ken-ichi"}],"nameIdentifiers":[{"nameIdentifier":"2743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Misawa, Aya"}],"nameIdentifiers":[{"nameIdentifier":"2744","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"2745","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagi, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"2746","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashizaki, Yoshihide"}],"nameIdentifiers":[{"nameIdentifier":"2747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimura, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"2748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Homma, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"2749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"2750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Urano, Tomohiko"}],"nameIdentifiers":[{"nameIdentifier":"2751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"2752","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-30"}],"displaytype":"detail","filename":"ncomms9219.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ncomms9219.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/730/files/ncomms9219.pdf"},"version_id":"a5ed2add-4be9-417e-bfef-49d0e76015d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biological sciences","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression"}]},"item_type_id":"2","owner":"1","path":["11","200"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-28"},"publish_date":"2016-03-28","publish_status":"0","recid":"730","relation_version_is_last":true,"title":["TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-19T03:41:44.922714+00:00"}