{"created":"2021-03-01T06:17:16.866914+00:00","id":735,"links":{},"metadata":{"_buckets":{"deposit":"55a07f87-635c-4844-ae7e-92b586f72ea1"},"_deposit":{"id":"735","owners":[],"pid":{"revision_id":0,"type":"depid","value":"735"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000735","sets":["75:207:208","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"11645","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alternative splicing generates protein diversity essential for neuronal properties. However, the precise mechanisms underlying this process and its relevance to physiological and behavioural functions are poorly understood. To address these issues, we focused on a cassette exon of the Caenorhabditis elegans insulin receptor gene daf-2, whose proper variant expression in the taste receptor neuron ASER is critical for taste-avoidance learning. We show that inclusion of daf-2 exon 11.5 is restricted to specific neuron types, including ASER, and is controlled by a combinatorial action of evolutionarily conserved alternative splicing factors, RBFOX, CELF and PTB families of proteins. Mutations of these factors cause a learning defect, and this defect is relieved by DAF-2c (exon 11.5þ) isoform expression only in a single neuron ASER. Our results provide evidence that alternative splicing regulation of a single critical gene in a single critical neuron is essential for learning ability in an organism.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「飢餓の記憶の形成に必要な分子が作られるしくみ」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/production-of-a-molecule-for-memory-of-salt-concentration.html","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"Production of a molecule for memory of salt concentration\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/production-of-a-molecule-for-memory-of-salt-concentration.html","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/ncomms11645","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/production-of-a-molecule-for-memory-of-salt-concentration.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/production-of-a-molecule-for-memory-of-salt-concentration.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/ncomms/2016/160520/ncomms11645/full/ncomms11645.html","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2016, Rights Managed by Nature Publishing Group"}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Molecular Genetics Research Laboratory, Graduate School of Science, The University of Tokyo"},{"subitem_text_value":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo"},{"subitem_text_value":"Medical Research Institute, Tokyo Medical and Dental University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomioka, 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MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ncomms11645.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/735/files/ncomms11645.pdf"},"version_id":"f17db600-5367-4dd8-9057-0ef6a7f2788c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biological sciences","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular biology","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuroscience","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor"}]},"item_type_id":"2","owner":"1","path":["11","208"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-06-23"},"publish_date":"2016-06-23","publish_status":"0","recid":"735","relation_version_is_last":true,"title":["Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T05:26:58.921610+00:00"}