{"created":"2021-03-01T06:17:17.175757+00:00","id":740,"links":{},"metadata":{"_buckets":{"deposit":"9b51570a-8798-42b9-9049-2eb5c5e957b1"},"_deposit":{"id":"740","owners":[],"pid":{"revision_id":0,"type":"depid","value":"740"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00000740","sets":["27:38:39","9:10:11"]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"28183","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Soy protein β-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that single ingestion of β-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating transcription factor 4 (ATF4), but not for peroxisome proliferator-activated receptor α. Overexpression of a dominant-negative form of ATF4 significantly reduced β-conglycinin-induced increases in hepatic FGF21 gene expression. In FGF21-deficient mice, β-conglycinin effects were partially abolished. Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling. Thus, dietary β-conglycinin intake can impact hepatic and systemic metabolism by increasing the postprandial circulating FGF21 levels.","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"UTokyo Research掲載「大豆のタンパク質1回摂取で代謝を改善する因子が急増」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html","subitem_description_type":"Other"},{"subitem_description":"UTokyo Research \"Single ingestion of soy protein improves metabolism\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html","subitem_description_type":"Other"}]},"item_2_publisher_20":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1038/srep28183","subitem_relation_type_select":"DOI"}}]},"item_2_relation_25":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/articles/srep28183","subitem_relation_type_select":"URI"}}]},"item_2_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2016, Rights Managed by Nature Publishing Group"}]},"item_2_select_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo"},{"subitem_text_value":"Institute of Gerontology, The University of Tokyo"},{"subitem_text_value":"Medical Innovation Center, Kyoto University Graduate School of Medicine"},{"subitem_text_value":"Department of Food Science and Nutrition, Nara Women’s University"},{"subitem_text_value":"RIKEN Center for Sustainable Resource Science"},{"subitem_text_value":"Faculty of Agriculture, Yamagata University"},{"subitem_text_value":"Institute for Food Science, Hirosaki University"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashidume, Tsutomu"}],"nameIdentifiers":[{"nameIdentifier":"2796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Asuka"}],"nameIdentifiers":[{"nameIdentifier":"2797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Tomohiro"}],"nameIdentifiers":[{"nameIdentifier":"2798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyoshi, Shoko"}],"nameIdentifiers":[{"nameIdentifier":"2799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itoh, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"2800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakata, Rieko"}],"nameIdentifiers":[{"nameIdentifier":"2801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Hiroyasu"}],"nameIdentifiers":[{"nameIdentifier":"2802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oikawa, Akira"}],"nameIdentifiers":[{"nameIdentifier":"2803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakai, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"2804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"2805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Jun"}],"nameIdentifiers":[{"nameIdentifier":"2806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Ryuichiro"}],"nameIdentifiers":[{"nameIdentifier":"2807","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-30"}],"displaytype":"detail","filename":"srep28183.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"srep28183.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/740/files/srep28183.pdf"},"version_id":"6bf111a9-2729-4c27-8d8b-960233305fec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Metabolic syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular biology","subitem_subject_scheme":"Other"},{"subitem_subject":"Obesity","subitem_subject_scheme":"Other"},{"subitem_subject":"Proteins","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects"}]},"item_type_id":"2","owner":"1","path":["11","39"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-14"},"publish_date":"2016-07-14","publish_status":"0","recid":"740","relation_version_is_last":true,"title":["Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-19T03:41:46.895513+00:00"}