{"created":"2021-03-01T06:24:13.529086+00:00","id":7451,"links":{},"metadata":{"_buckets":{"deposit":"ff46772a-88b3-4d10-8afb-9616bef65bf9"},"_deposit":{"id":"7451","owners":[],"pid":{"revision_id":0,"type":"depid","value":"7451"},"status":"published"},"_oai":{"id":"oai:repository.dl.itc.u-tokyo.ac.jp:00007451","sets":["125:220:350","9:233:280"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"生後発達期における小脳プルキンエ細胞集団活動の非同期化"}]},"item_7_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_25":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-03-25"}]},"item_7_degree_grantor_23":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"University of Tokyo (東京大学)"}]}]},"item_7_degree_name_20":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The inferior olive of the medulla oblongata sends glutamatergic afferents to the cerebellum. In adult rodents, axons of inferior olivary neurons divide into several climbing fibers (CFs) that innervate cerebellar Purkinje cells (PCs) in a one-to-one manner. Activation of CFs generates bursts of action potentials known as complex spikes (CSs) in PCs. CSs in neighboring PCs are synchronized due to electrical coupling between inferior olivary neurons. During early postnatal period, however, the pattern of CS activity in populations of PCs remains unclear. CF-PC synapses undergo dynamic changes during the first two postnatal weeks including selective strengthening of a single CF and elimination of redundant CFs in each PC. In this study, I used in vivo two-photon calcium imaging to monitor CS activity from populations of PCs during the period of the CF network refinement. I found that CS activity was highly correlated among neighboring PCs in newborn mice and progressively desynchronized during the first postnatal week. The degree of synchrony declined to the adult level at postnatal day 8. I also analyzed PC-specific Cav 2.1 knockout mouse, in which selective strengthening of a single CF and elimination of redundant CFs in each PC is impaired. The progressive desynchronization of CS activity observed in wild-type mice was incomplete in the knockout mice. These results suggest that the configuration of the CF network has a direct impact on the pattern of CS activity in PC populations and that the desynchronization of CS activity might result from the CF network refinement.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15104","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ジャンマルク, グッド"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15083/00007442","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_21":{"attribute_name":"学位","attribute_value_mlt":[{"subitem_select_item":"doctoral"}]},"item_7_text_22":{"attribute_name":"学位分野","attribute_value_mlt":[{"subitem_text_value":"Medical Science(医学)"}]},"item_7_text_24":{"attribute_name":"研究科・専攻","attribute_value_mlt":[{"subitem_text_value":"Department of Functional Biology, Graduate School of Medicine(医学系研究科機能生物学専攻)"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東京大学医学系研究科機能生物学専攻"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jean-Marc, Good"}],"nameIdentifiers":[{"nameIdentifier":"15103","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-02"}],"displaytype":"detail","filename":"H24_4011_good.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24_4011_good.pdf","url":"https://repository.dl.itc.u-tokyo.ac.jp/record/7451/files/H24_4011_good.pdf"},"version_id":"d697c160-833c-4649-8982-e4dd7555701d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Desynchronization of cerebellar Purkinje cell population activity during postnatal development","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Desynchronization of cerebellar Purkinje cell population activity during postnatal development"}]},"item_type_id":"7","owner":"1","path":["280","350"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-04"},"publish_date":"2016-04-04","publish_status":"0","recid":"7451","relation_version_is_last":true,"title":["Desynchronization of cerebellar Purkinje cell population activity during postnatal development"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-19T03:50:00.449529+00:00"}