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  1. 115 理学系研究科・理学部
  2. 14 生物科学専攻
  3. 1151410 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data

http://hdl.handle.net/2261/56077
http://hdl.handle.net/2261/56077
f41d4f45-9ac5-4fe7-bacc-3288a032a800
名前 / ファイル ライセンス アクション
1-s2.0-S2211124714005907-main.pdf 1-s2.0-S2211124714005907-main.pdf (4.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-02-04
タイトル
タイトル Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yugi, Katsuyuki

× Yugi, Katsuyuki

WEKO 2340

Yugi, Katsuyuki

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Kubota, Hiroyuki

× Kubota, Hiroyuki

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Kubota, Hiroyuki

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Toyoshima, Yu

× Toyoshima, Yu

WEKO 2342

Toyoshima, Yu

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Noguchi, Rei

× Noguchi, Rei

WEKO 2343

Noguchi, Rei

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Kawata, Kentaro

× Kawata, Kentaro

WEKO 2344

Kawata, Kentaro

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Komori, Yasunori

× Komori, Yasunori

WEKO 2345

Komori, Yasunori

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Uda, Shinsuke

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WEKO 2346

Uda, Shinsuke

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Kunida, Katsuyuki

× Kunida, Katsuyuki

WEKO 2347

Kunida, Katsuyuki

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Tomizawa, Yoko

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WEKO 2348

Tomizawa, Yoko

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Funato, Yosuke

× Funato, Yosuke

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Funato, Yosuke

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Miki, Hiroaki

× Miki, Hiroaki

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Miki, Hiroaki

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Matsumoto, Masaki

× Matsumoto, Masaki

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Matsumoto, Masaki

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Nakayama, Keiichi I.

× Nakayama, Keiichi I.

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Nakayama, Keiichi I.

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Kashikura, Kasumi

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Kashikura, Kasumi

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Endo, Keiko

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Endo, Keiko

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Ikeda, Kazutaka

× Ikeda, Kazutaka

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Ikeda, Kazutaka

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Soga, Tomoyoshi

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Soga, Tomoyoshi

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Kuroda, Shinya

× Kuroda, Shinya

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Kuroda, Shinya

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著者所属
著者所属 Department of Biological Sciences, Graduate School of Science, University of Tokyo
著者所属
著者所属 Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo
著者所属
著者所属 Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University
著者所属
著者所属 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
著者所属
著者所属 Institute for Advanced Biosciences, Keio University
著者所属
著者所属 CREST, Japan Science and Technology Corporation
著者所属
著者所属 Division of integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
著者所属
著者所属 PRESTO, Japan Science and Technology Corporation
抄録
内容記述タイプ Abstract
内容記述 Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored. We have developed a reconstruction method for the signal flow based on time-course phosphoproteome and metabolome data, using multiple databases, and have applied it to acute action of insulin, an important hormone for metabolic homeostasis. An insulin signal flows through a network, through signaling pathways that involve 13 protein kinases, 26 phosphorylated metabolic enzymes, and 35 allosteric effectors, resulting in quantitative changes in 44 metabolites. Analysis of the network reveals that insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, thereby controlling a key reaction in glycolysis. We thus provide a versatile method of reconstruction of signal flow through the network using phosphoproteome and metabolome data.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「細胞内のビッグデータから大規模ネットワークの再構築に成功」URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "Reconstruction of molecular network from cellular big data" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/
書誌情報 Cell Reports

巻 8, 号 4, p. 1171-1183, 発行日 2014-08-21
ISSN
収録物識別子タイプ ISSN
収録物識別子 2211-1247
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.celrep.2014.07.021
権利
権利情報 © 2014 The Authors; This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
出版者
出版者 Elsevier
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/
関係URI
識別子タイプ URI
関連識別子 http://www.sciencedirect.com/science/article/pii/S2211124714005907
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