WEKO3
アイテム
Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data
http://hdl.handle.net/2261/56077
http://hdl.handle.net/2261/56077f41d4f45-9ac5-4fe7-bacc-3288a032a800
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1-s2.0-S2211124714005907-main.pdf (4.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-02-04 | |||||
| タイトル | ||||||
| タイトル | Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Yugi, Katsuyuki
× Yugi, Katsuyuki× Kubota, Hiroyuki× Toyoshima, Yu× Noguchi, Rei× Kawata, Kentaro× Komori, Yasunori× Uda, Shinsuke× Kunida, Katsuyuki× Tomizawa, Yoko× Funato, Yosuke× Miki, Hiroaki× Matsumoto, Masaki× Nakayama, Keiichi I.× Kashikura, Kasumi× Endo, Keiko× Ikeda, Kazutaka× Soga, Tomoyoshi× Kuroda, Shinya |
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| 著者所属 | ||||||
| 著者所属 | Department of Biological Sciences, Graduate School of Science, University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University | |||||
| 著者所属 | ||||||
| 著者所属 | Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University | |||||
| 著者所属 | ||||||
| 著者所属 | Institute for Advanced Biosciences, Keio University | |||||
| 著者所属 | ||||||
| 著者所属 | CREST, Japan Science and Technology Corporation | |||||
| 著者所属 | ||||||
| 著者所属 | Division of integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University | |||||
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| 著者所属 | PRESTO, Japan Science and Technology Corporation | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cellular homeostasis is regulated by signals through multiple molecular networks that include protein phosphorylation and metabolites. However, where and when the signal flows through a network and regulates homeostasis has not been explored. We have developed a reconstruction method for the signal flow based on time-course phosphoproteome and metabolome data, using multiple databases, and have applied it to acute action of insulin, an important hormone for metabolic homeostasis. An insulin signal flows through a network, through signaling pathways that involve 13 protein kinases, 26 phosphorylated metabolic enzymes, and 35 allosteric effectors, resulting in quantitative changes in 44 metabolites. Analysis of the network reveals that insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, thereby controlling a key reaction in glycolysis. We thus provide a versatile method of reconstruction of signal flow through the network using phosphoproteome and metabolome data. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「細胞内のビッグデータから大規模ネットワークの再構築に成功」URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/ | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "Reconstruction of molecular network from cellular big data" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/ | |||||
| 書誌情報 |
Cell Reports 巻 8, 号 4, p. 1171-1183, 発行日 2014-08-21 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2211-1247 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.celrep.2014.07.021 | |||||
| 権利 | ||||||
| 権利情報 | © 2014 The Authors; This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/ | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/reconstruction-of-molecular-network-from-cellular-big-data/ | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science/article/pii/S2211124714005907 | |||||
