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An orthogonal ribosome-tRNAs pair via engineering of the peptidyl transferase center
http://hdl.handle.net/2261/56497
http://hdl.handle.net/2261/564972207e8ef-252d-4b73-b13e-cb185443533e
名前 / ファイル | ライセンス | アクション |
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nchembio.1549_author_version.pdf (879.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-02-26 | |||||
タイトル | ||||||
タイトル | An orthogonal ribosome-tRNAs pair via engineering of the peptidyl transferase center | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Terasaka, Naohiro
× Terasaka, Naohiro× Hayashi, Gosuke× Katoh, Takayuki× Suga, Hiroaki |
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著者所属 | ||||||
著者所属 | Department of Chemistry, Graduate School of Science, University of Tokyo | |||||
著者所属 | ||||||
著者所属 | Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, University of Tokyo | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Watson-Crick base pairs between the 3'-terminal end of tRNAs and ribosomal RNA in the peptidyl transferase center are universally conserved. Here, we report that the introduction of compensatory mutations to Escherichia coli RNAs in this site leads to an orthogonal system independent of the wild-type counterpart, as demonstrated via the production of two peptide sequences from a single mRNA. This work thus identifies a new way to reprogram the genetic code. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | UTokyo Research掲載「1つの遺伝子から2種類のペプチドが同時に翻訳合成できる?!」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/simultaneous-translation-of-two-distinct-peptides-from-single-mrna-template/ | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | UTokyo Research "Simultaneous translation of two distinct peptides from single mRNA template" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/simultaneous-translation-of-two-distinct-peptides-from-single-mrna-template/ | |||||
書誌情報 |
Nature chemical biology 巻 10, p. 555-557, 発行日 2014-06-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1552-4450 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1552-4469 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11994319 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/nchembio.1549 | |||||
権利 | ||||||
権利情報 | Copyright (C) 2014, Rights Managed by Nature Publishing Group | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Nature Publishing Group | |||||
関係URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/simultaneous-translation-of-two-distinct-peptides-from-single-mrna-template/ | |||||
関係URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/simultaneous-translation-of-two-distinct-peptides-from-single-mrna-template/ | |||||
関係URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/nchembio/journal/v10/n7/abs/nchembio.1549.html |