| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-02-22 |
| タイトル |
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|
タイトル |
Age-associated CD4+ T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.15083/0002009579 |
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ID登録タイプ |
JaLC |
| 著者 |
Goto, Manaka
Takahashi, Hideyuki
Yoshida, Ryochi
Itamiya, Takahiro
Nakano, Masahiro
Nagafuchi, Yasuo
Harada, Hiroaki
Shimizu, Toshiaki
Maeda, Meiko
Kubota, Akatsuki
Toda, Tatsushi
Hatano, Hiroaki
Sugimori, Yusuke
Kawahata, Kimito
Yamamoto, Kazuhiko
| en |
Yamamoto, Kazuhiko
RIKEN Center for Integrative Medical Sciences
|
Search repository
Shoda, Hirofumi
Ishigaki, Kazuyoshi
| en |
Ishigaki, Kazuyoshi
RIKEN Center for Integrative Medical Sciences
|
Search repository
Ota, Mineto
Okamura, Tomohisa
Fujio, Keishi
|
| 著者所属 |
|
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言語 |
en |
|
著者所属 |
Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo |
| 著者所属 |
|
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言語 |
en |
|
著者所属 |
Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo |
| 著者所属 |
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言語 |
en |
|
著者所属 |
Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences |
| 著者所属 |
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言語 |
en |
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著者所属 |
Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences |
| 著者所属 |
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言語 |
en |
|
著者所属 |
Department of Neurology, Graduate School of Medicine, The University of Tokyo |
| 著者所属 |
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言語 |
en |
|
著者所属 |
Department of Rheumatology and Allergology, St. Marianna University School of Medicine |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Aging is a significant risk factor for autoimmunity, and many autoimmune diseases tend to onset during adulthood. We conducted an extensive analysis of CD4+ T cell subsets from 354 autoimmune disease patients and healthy controls via flow cytometry and bulk RNA sequencing. As a result, we identified a distinct CXCR3midCD4+ effector memory T cell subset that expands with age, which we designated “age-associated helper T (ThA) cells”. ThA cells exhibited both a cytotoxic phenotype and B cell helper functions, and these features were regulated by the transcription factor ZEB2. Consistent with the highly skewed T cell receptor usage of ThA cells, gene expression in ThA cells from systemic lupus erythematosus patients reflected disease activity and was affected by treatment with a calcineurin inhibitor. Moreover, analysis of single-cell RNA sequencing data revealed that ThA cells infiltrate damaged organs in patients with autoimmune diseases. Together, our characterization of ThA cells may facilitate improved understanding of the relationship between aging and autoimmune diseases. |
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言語 |
en |
| 書誌情報 |
en : Science Immunology
p. 0,
発行日 2024-02-08
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
24709468 |
| 権利 |
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言語 |
en |
|
権利情報 |
This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Immunology on Feb 8, 2024 (US ET), DOI: 10.1126/sciimmunol.adk1643, URL：https://www.science.org/doi/10.1126/sciimmunol.adk1643 この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| 出版者 |
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出版者 |
American Association for the Advancement of Science |
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言語 |
en |
| 関係URI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1126/sciimmunol.adk1643 |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Science_Immunology_Goto_et_al_adk1643_Author's_version.pdf (5.1 MB)
