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  1. 112 医学系研究科・医学部
  2. 18 外科学専攻
  3. 1121820 博士論文(外科学専攻)
  1. 0 資料タイプ別
  2. 20 学位論文
  3. 021 博士論文

Interactions between right and left olfactory cortices via the anterior commissure

https://doi.org/10.15083/00002310
https://doi.org/10.15083/00002310
31497736-b7c8-4c83-a374-430ba7412426
名前 / ファイル ライセンス アクション
41_kikuta.pdf 41_kikuta.pdf (47.0 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-03-01
タイトル
タイトル Interactions between right and left olfactory cortices via the anterior commissure
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
ID登録
ID登録 10.15083/00002310
ID登録タイプ JaLC
その他のタイトル
その他のタイトル 前交連を介した左右嗅皮質間の相互作用
著者 菊田, 周

× 菊田, 周

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菊田, 周

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著者所属
著者所属 東京大学大学院医学系研究科外科学専攻耳鼻咽喉科
Abstract
内容記述タイプ Abstract
内容記述 Visual and auditory systems use two sensory organs to monitor the external sensory signals. In olfactory systems, odors are inhaled through the nostrils into two segregated nasal passages and processed by two, right and left olfactory pathways. Anterior olfactory nucleus (AON) of the adult rat olfactory cortex receives excitatory axonal inputs from ipsi-lateral olfactory bulb and also receives inputs from contra-lateral olfactory cortex via the anterior commissure (AC), suggesting that it receives converging inputs from ipsi-lateral and contra-lateral olfactory epithelia. To study the functional interactions between right and left olfactory pathways, I recorded extracellular single unit activity of AON neurons and examined their responses to ipsi-nasal and contra-nasal stimulation with 10 odorant categories. I found 1) that about 60 % neurons in the AON received converging excitatory inputs from both olfactory epithelia, 2) that these binasal neurons were preferentially located in the deep part of the layerⅡ in the AON, and 3) that binasal neurons in the AON respond to ipsi-nasal and contra-nasal inputs with nearly-equivalent odorant category selectivity. Furthermore, deprivation of ipsi-nasal inputs by unilateral nostril obstruction greatly enhanced the response to contra-lateral odor stimulation, in a reversible manner, in about 33% of AON neurons within only several minutes. In 27% of AON neurons that showed spike responses induced by the inspiration of room air, ipsi-lateral nasal obstruction initially suppressed respiration phase-locked spike discharges and, several minutes later, induced respiration phase-locked discharges with longer delays between inspiration and response. Recordings from AON neurons in rats with AC transection indicated that the resumed respiration phase-locked discharges with longer delays were mediated by the contra-lateral pathway via the AC. The ipsi-nasal occlusion-induced switching of nasal inputs to individual AON neurons shows that a subset of AON neurons in the adult rat has neuronal mechanisms for rapid nostril dominance plasticity, which may enable both right and left olfactory cortices to preserve their responsiveness to the external odor world, despite reciprocal changes in nasal airflow
書誌情報 発行日 2009-03-23
学位名
学位名 博士(医学)
学位
値 doctoral
学位分野
Medical Science (医学)
学位授与機関
学位授与機関名 University of Tokyo (東京大学)
研究科・専攻
Department of Surgical Sciences, Graduate School of Medicine (医学系研究科外科学専攻)
学位授与年月日
学位授与年月日 2009-03-23
学位授与番号
学位授与番号 甲第24894号
学位記番号
博医第3314号
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