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Elucidation of the mechanisms underlying the chemomechanical energy conversion by the dynein arms and their orchestrated movement in cilia/flagella is of great importance, but the nucleotide-dependent three-dimensional (3D) movement of dynein has not yet been observed. In this study, \u0399 establish a new method for reconstructing the 3D structure of the in vitro reconstituted ODA\u2013microtubule complex and visualize nucleotide-dependent conformational changes using cryoelectron microscopy and image analysis. As the complex went from the rigor state to the relaxed state, the head domain of the \u00df heavy chain shifted by 3.7 nm toward the B tubule and inclined 44\u00b0 inwards. These observations suggest that there is a mechanism that converts head movement into the axonemal sliding motion.", "subitem_description_type": "Abstract"}]}, "item_7_dissertation_number_26": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "\u7532\u7b2c24771\u53f7"}]}, "item_7_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.15083/00002325", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_select_21": {"attribute_name": "\u5b66\u4f4d", "attribute_value_mlt": [{"subitem_select_item": "doctoral"}]}, "item_7_text_22": {"attribute_name": "\u5b66\u4f4d\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "Medical Science (\u533b\u5b66)"}]}, "item_7_text_24": {"attribute_name": "\u7814\u7a76\u79d1\u30fb\u5c02\u653b", "attribute_value_mlt": [{"subitem_text_value": "Department of Molecular Cell Biology, Graduate School of Medicine (\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b66\u5c02\u653b)"}]}, "item_7_text_27": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u535a\u533b\u7b2c3191\u53f7"}]}, "item_7_text_36": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Thesis"}]}, "item_7_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b66\u5c02\u653b"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5c0f\u7530, \u8ce2\u5e78"}], "nameIdentifiers": [{"nameIdentifier": "6534", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "41_oda.pdf", "filesize": [{"value": "15.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 15300000.0, "url": {"label": "41_oda.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/2331/files/41_oda.pdf"}, "version_id": "e7f79a16-6ae5-48d0-b93a-57b1b810eb09"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy"}]}, "item_type_id": "7", "owner": "1", "path": ["9/233/280", "125/358/359"], "permalink_uri": "https://doi.org/10.15083/00002325", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2012-03-01"}, "publish_date": "2012-03-01", "publish_status": "0", "recid": "2331", "relation": {}, "relation_version_is_last": true, "title": ["Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy"], "weko_shared_id": null}