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血管平滑筋細胞におけるアルドステロンによるオステオポンチン遺伝子転写活性化機序の解析
https://doi.org/10.15083/00002449
c296743c-b747-485e-b3f5-6fd18ff07028
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2012-03-01 | |||||
タイトル | ||||||
タイトル | 血管平滑筋細胞におけるアルドステロンによるオステオポンチン遺伝子転写活性化機序の解析 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
ID登録 | ||||||
ID登録 | 10.15083/00002449 | |||||
ID登録タイプ | JaLC | |||||
その他のタイトル | ||||||
その他のタイトル | Analysis of mechanisms of osteopontin gene transcription regulation by aldosterone in vascular smooth muscle cells | |||||
著者 |
清末, 有宏
× 清末, 有宏 |
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著者所属 | ||||||
著者所属 | 大学院医学系研究科 内科学専攻 | |||||
Abstract | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | アルドステロン(Aldo)の催炎症作用に関与していると考えられるオステオポンチン(OPN)遺伝子の転写活性化機序について検討した。Aldo 刺激によるOPN 遺伝子転写亢進はミネラロコルチコイド受容体(MR)拮抗剤によって有意に減弱したためMR を介していると考えられた。また転写開始部位の-1404 から存在するglucocorticoid response element (GRE) を欠損したpromoter はAldoによる活性化能を失っていたことから、Aldo-MR 複合体はGRE へ結合しOPN転写量を調節していると考えられた。 | |||||
書誌情報 | 発行日 2010-03-24 | |||||
日本十進分類法 | ||||||
主題 | 490 | |||||
主題Scheme | NDC | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位 | ||||||
値 | doctoral | |||||
学位分野 | ||||||
Medical Science (医学) | ||||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | University of Tokyo (東京大学) | |||||
研究科・専攻 | ||||||
Department of Internal Medicine, Graduate School of Medicine (医学系研究科内科学専攻) | ||||||
学位授与年月日 | ||||||
学位授与年月日 | 2010-03-24 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第25981号 | |||||
学位記番号 | ||||||
博医第3460号 |