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創傷治癒過程における脂肪由来幹細胞の役割 : マウス虚血再灌流障害モデルを用いた実験
https://doi.org/10.15083/00002452
6207c3ac-228d-4b58-afe8-a3cc30521393
| 名前 / ファイル | ライセンス | アクション | |
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h21_suga.pdf (2.1 MB)
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h21_suga_a.pdf (189.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-03-01 | |||||
| タイトル | ||||||
| タイトル | 創傷治癒過程における脂肪由来幹細胞の役割 : マウス虚血再灌流障害モデルを用いた実験 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| ID登録 | ||||||
| ID登録 | 10.15083/00002452 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
菅, 浩隆
× 菅, 浩隆 |
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| 著者所属 | ||||||
| 大学院医学系研究科 外科学専攻 | ||||||
| Abstract | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 創傷治癒過程における脂肪由来幹細胞（ASCs）の役割を解明するため，細胞増殖因子に着目して実験を行った。まず， FGF-2 の刺激によりASCs の増殖とHGF 発現が促進されること，そして，これらにはJNK 経路が関与していることが判明した。マウスを用いた実験では，創傷治癒過程の初期にFGF-2 が大量に放出され，引き続いてASCs の増殖やHGF 発現亢進が認められた。抗FGF-2 中和抗体やJNK 阻害剤を投与すると，ASCs の増殖やHGF発現亢進が抑制され，さらに治癒後の線維化が増加した。これらの結果から，ASCs はFGF-2の刺激に呼応し，主にJNK 経路を介して増殖およびHGF 分泌を促進することにより，創傷治癒過程の脂肪組織再生や線維化抑制において重要な役割を果たしていると考えられた。 | |||||
| 書誌情報 | 発行日 2010-03-24 | |||||
| 日本十進分類法 | ||||||
| 主題 | 490 | |||||
| 主題Scheme | NDC | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位 | ||||||
| 値 | doctoral | |||||
| 学位分野 | ||||||
| Medical Science (医学) | ||||||
| 学位授与機関 | ||||||
| 学位授与機関名 | ||||||
| 学位授与機関名 | University of Tokyo (東京大学) | |||||
| 研究科・専攻 | ||||||
| Department of Surgical Sciences, Graduate School of Medicine (医学系研究科外科学専攻) | ||||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2010-03-24 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第26028号 | |||||
| 学位記番号 | ||||||
| 博医第3507号 | ||||||
