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Immigrants to the Nucleus : Analysis of Mitochondrially Derived Nuclear Genomic Regions (NUMT)
http://hdl.handle.net/2261/37244
http://hdl.handle.net/2261/37244b7845d15-bfd4-4de1-8526-b77712c77cf7
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本文(fulltext) (2.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2012-10-12 | |||||
| タイトル | ||||||
| タイトル | Immigrants to the Nucleus : Analysis of Mitochondrially Derived Nuclear Genomic Regions (NUMT) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nuclear genome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mitochondrial DNA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NUMT | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mitochondrial pseudogene | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | retrotransposon | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | exogenous DNA element | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| 著者 |
辻, 淳子
× 辻, 淳子 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 9265 | |||||
| 姓名 | Tsuji, Junko | |||||
| 著者所属 | ||||||
| 著者所属 | 東京大学大学院新領域創成科学研究科情報生命科学専攻 | |||||
| Abstract | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | From the origin of eukaryotic cells to the present, mitochondrial DNA (mtDNA) fragments continuously have transferred to the nucleus and become nuclear mitochondrial-like DNAs (NUMT). Previous studies concluded that NUMT candidate mtDNA sequences and nuclear NUMT insertion sites are randomly chosen. However, from analyzing 310 human NUMT, we found specific mtDNA transferred pattern and NUMT preference features of nuclear genome. Our result suggests that the mitochondrial promoter region and its peripheral domains (548bp-1142bp counted by D-loop as the origin) were seldom transferred. In NUMT preferentially integrated sites of human genome, AT-rich oligomers appeared in all NUMTs flank and 90% of NUMTs contained retrotransposons in their flanks (more than expected by change, P-value = 0.001). The retrotransposon-encoded endonuclease recognizes AT-rich oligomers (5’-TTTTAA-3’). This suggests retrotransposon-encoded endonuclease may be involved in NUMT insertion. We also crosschecked our NUMT dataset against annotation databases. Almost all NUMTs were non-coding (nc) regions or introns. Only 1~2% of NUMTs have annotated functional roles in human and mouse genome. They were mainly ncRNAs, and those functional human and mouse NUMTs were inserted relatively recently in evolutionary time. Interestingly, one of the human specific functional NUMTs is an ncRNA which is expressed during fetal brain development. Hence, it is conceivable that this element might contribute to the difference between human and chimpanzee brain structure. | |||||
| 書誌情報 | 発行日 2010-03-24 | |||||
| 学位名 | ||||||
| 学位名 | 修士(科学) | |||||
| 学位 | ||||||
| 値 | master | |||||
| 研究科・専攻 | ||||||
| 新領域創成科学研究科情報生命科学専攻 | ||||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2010-03-24 | |||||
| 学位記番号 | ||||||
| 修創域第3598号 | ||||||
