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Electron transfer pathways in a multiheme cytochrome MtrF
http://hdl.handle.net/2261/00074026
http://hdl.handle.net/2261/0007402614b6c3f1-f207-4a5a-8396-c096beeb7966
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
MtrF_PNAS_2.3.pdf (220.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-28 | |||||
| タイトル | ||||||
| タイトル | Electron transfer pathways in a multiheme cytochrome MtrF | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | decaheme | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dissimilatory metal-reducing bacteria | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | flavin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Shewanella species | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mtr conduit | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Watanabe, Hiroshi C.
× Watanabe, Hiroshi C.× Yamashita, Yuki× Ishikita, Hiroshi |
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| 著者所属 | ||||||
| 値 | Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo | |||||
| 著者所属 | ||||||
| 値 | Research Center for Advanced Science and Technology, The University of Tokyo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In MtrF, an outer-membrane multiheme cytochrome, the 10 heme groups are arranged in heme binding domains II and IV along the pseudo-C2 axis, forming the electron transfer (ET) pathways. Previous reports based on molecular dynamics simulations showed that the redox potential (Em) values for the heme pairs located in symmetrical positions in domains II and IV were similar, forming bidirectional ET pathways [Breuer M, Zarzycki P, Blumberger J, Rosso KM (2012) J Am Chem Soc 134(24):9868–9871]. Here, we present the Em values of the 10 hemes in MtrF, solving the linear Poisson–Boltzmann equation and considering the protonation states of all titratable residues and heme propionic groups. In contrast to previous studies, the Em values indicated that the ET is more likely to be downhill from domain IV to II because of localization of acidic residues in domain IV. Reduction of hemes in MtrF lowered the Em values, resulting in switching to alternative downhill ET pathways that extended to the flavin binding sites. These findings present an explanation of how MtrF serves as an electron donor to extracellular substrates. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「天然のダイオードタンパク質」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/Protein-acts-as-natural-diode.html | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "Protein acts as natural diode" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/Protein-acts-as-natural-diode.html | |||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United State of America Online Edition 巻 114, 号 11, p. 2916-2921, 発行日 2017-03-14 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1091-6490 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11726874 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1073/pnas.1617615114 | |||||
| 権利 | ||||||
| 権利情報 | the author(s) retains copyright to individual articles, and the National Academy of Sciences of the United States of America retains an exclusive license to publish these articles and holds copyright to the collective work. | |||||
| 著者版フラグ | ||||||
| 値 | author | |||||
| 出版者 | ||||||
| 出版者 | National Academy of Sciences | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/Protein-acts-as-natural-diode.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/Protein-acts-as-natural-diode.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.pnas.org/content/114/11/2916 | |||||
