{"_buckets": {"deposit": "0762aac3-b85b-4ae0-a45f-dd720ae7c298"}, "_deposit": {"id": "53881", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "53881"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00053881"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-11-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "607", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "Science Signaling"}]}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "This is the author\u2019s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Signaling on 12 Nov 2019:Vol. 12, Issue 607, DOI: 10.1126/scisignal.aay4430", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo FOCUS Articles \"Gene causing rare heart and lung disease identified : Genomewide screening, animal studies used in long-term research on pulmonary arterial hypertension\" https://www.u-tokyo.ac.jp/focus/en/articles/z0508_00081.html", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "American Association for the Advancement of Science"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1126/scisignal.aay4430 ", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://www.u-tokyo.ac.jp/focus/en/articles/z0508_00081.html"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.u-tokyo.ac.jp/focus/en/articles/z0508_00081.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://doi.org/10.1126/scisignal.aay4430"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1126/scisignal.aay4430", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_26": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://doi.org/10.1126/scisignal.aay4430"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1126/scisignal.aay4430", "subitem_relation_type_select": "URI"}}]}, "item_2_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works."}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1945-0877", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University"}, {"subitem_text_value": "Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University"}, {"subitem_text_value": "Department of Pediatrics, Mie University Graduate School of Medicine"}, {"subitem_text_value": "Genome Engineering Zebrafish Facility, Science For Life Laboratory, Uppsala University"}, {"subitem_text_value": "Department of Anesthesiology, Mie University Graduate School of Medicine"}, {"subitem_text_value": "Institute for Frontier Life and Medical Sciences, Kyoto University"}, {"subitem_text_value": "Department of Medical Joint Materials, Kagoshima University"}, {"subitem_text_value": "Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Morikawa, Masato"}], "nameIdentifiers": [{"nameIdentifier": "159890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitani, Yoshihide"}], "nameIdentifiers": [{"nameIdentifier": "159891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Holmborn, Katarina"}], "nameIdentifiers": [{"nameIdentifier": "159892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Taichi"}], "nameIdentifiers": [{"nameIdentifier": "159893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koinuma, Daizo"}], "nameIdentifiers": [{"nameIdentifier": "159894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Junko"}], "nameIdentifiers": [{"nameIdentifier": "159895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Vasilaki, Eleftheria"}], "nameIdentifiers": [{"nameIdentifier": "159896", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawada, Hirofumi"}], "nameIdentifiers": [{"nameIdentifier": "159897", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Mai"}], "nameIdentifiers": [{"nameIdentifier": "159898", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozawa, Takayuki"}], "nameIdentifiers": [{"nameIdentifier": "159899", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morishita, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "159900", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bessho, Yasumasa"}], "nameIdentifiers": [{"nameIdentifier": "159901", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "159902", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ledin, Johan"}], "nameIdentifiers": [{"nameIdentifier": "159903", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aburatani, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "159904", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kageyama, Ryoichiro"}], "nameIdentifiers": [{"nameIdentifier": "159905", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Kazuo"}], "nameIdentifiers": [{"nameIdentifier": "159906", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Heldin, Carl-Henrik"}], "nameIdentifiers": [{"nameIdentifier": "159907", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazono, Kohei"}], "nameIdentifiers": [{"nameIdentifier": "159908", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Morikawa_et_al_AuthorFinal.pdf", "filesize": [{"value": "338.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 338700.0, "url": {"label": "Morikawa_et_al_AuthorFinal.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Morikawa_et_al_AuthorFinal.pdf"}, "version_id": "1e91b59b-16e0-486a-984d-8523fef45bf7"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Figure1_BMP_nonNotch.tif", "filesize": [{"value": "12.0 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 12000000.0, "url": {"label": "Figure1_BMP_nonNotch.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure1_BMP_nonNotch.tif"}, "version_id": "f4278971-f528-48a0-8157-e45eeb2bce21"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "Figure2_enhancer.tif", "filesize": [{"value": "15.0 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 15000000.0, "url": {"label": "Figure2_enhancer.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure2_enhancer.tif"}, "version_id": "0ae991a0-3691-49eb-afe6-68eeacb5a9d3"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 3, "filename": "Figure3_zebrafish.tif", "filesize": [{"value": "14.1 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 14100000.0, "url": {"label": "Figure3_zebrafish.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure3_zebrafish.tif"}, "version_id": "d44099bc-1df8-4017-97b0-8bbad751dcb6"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 4, "filename": "Figure4_mouse_retinal_angiogenesis.tif", "filesize": [{"value": "9.7 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 9700000.0, "url": {"label": "Figure4_mouse_retinal_angiogenesis.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure4_mouse_retinal_angiogenesis.tif"}, "version_id": "eddbf7cf-dd2f-4eae-a719-d687a92c1ec6"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 5, "filename": "Figure5_PPH.tif", "filesize": [{"value": "16.0 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 16000000.0, "url": {"label": "Figure5_PPH.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure5_PPH.tif"}, "version_id": "97ebdc9f-259c-4fce-85dd-3e2c23b2f2bb"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 6, "filename": "Figure6_HUVEC_and_HPAEC.tif", "filesize": [{"value": "12.5 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 12500000.0, "url": {"label": "Figure6_HUVEC_and_HPAEC.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure6_HUVEC_and_HPAEC.tif"}, "version_id": "1f2081b5-727e-4c58-a518-49b932f5c2e3"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 7, "filename": "Figure7_ATOH8andHIF2a.tif", "filesize": [{"value": "14.2 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 14200000.0, "url": {"label": "Figure7_ATOH8andHIF2a.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure7_ATOH8andHIF2a.tif"}, "version_id": "b73b33a5-6358-4400-9689-a8446b7d94dc"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 8, "filename": "Figure8_HPAEC_hypoxia.tif", "filesize": [{"value": "13.6 MB"}], "format": "image/tiff", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "image/tiff", "size": 13600000.0, "url": {"label": "Figure8_HPAEC_hypoxia.tif", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/Figure8_HPAEC_hypoxia.tif"}, "version_id": "7a5e3e9c-824c-461c-b148-b1a163d78ece"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 9, "filename": "aay4430_SupplementalMaterial.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "aay4430_SupplementalMaterial.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/aay4430_SupplementalMaterial.pdf"}, "version_id": "f67ccd70-6216-4bce-a90a-4933d3261cf3"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 10, "filename": "TableS1.xlsx", "filesize": [{"value": "12.7 kB"}], "format": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "size": 12700.0, "url": {"label": "TableS1.xlsx", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/TableS1.xlsx"}, "version_id": "a59801ae-97de-477b-a1e3-78cb3a065f55"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 11, "filename": "TableS2.xlsx", "filesize": [{"value": "11.2 kB"}], "format": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "size": 11200.0, "url": {"label": "TableS2.xlsx", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/TableS2.xlsx"}, "version_id": "ddbf6c3d-d387-4876-8ac2-9677790b3e4f"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 12, "filename": "TableS3.xlsx", "filesize": [{"value": "12.4 kB"}], "format": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "size": 12400.0, "url": {"label": "TableS3.xlsx", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/TableS3.xlsx"}, "version_id": "725db626-1e22-4fea-b0aa-4cb16146c3bc"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 13, "filename": "TableS4.xlsx", "filesize": [{"value": "10.7 kB"}], "format": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "size": 10700.0, "url": {"label": "TableS4.xlsx", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/53881/files/TableS4.xlsx"}, "version_id": "7c8228b7-5e36-4356-aae9-50722cc5e55a"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension"}]}, "item_type_id": "2", "owner": "1", "path": ["9/10/11", "125/197/198"], "permalink_uri": "http://hdl.handle.net/2261/00078998", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2020-05-14"}, "publish_date": "2020-05-14", "publish_status": "0", "recid": "53881", "relation": {}, "relation_version_is_last": true, "title": ["The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension"], "weko_shared_id": 2}