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Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals
http://hdl.handle.net/2261/56501
http://hdl.handle.net/2261/56501a23d33ed-4955-427d-b88a-01dba4b9a430
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
GenomeRes.-2014-Niimura-gr.169532.113.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-02-26 | |||||
| タイトル | ||||||
| タイトル | Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Niimura, Yoshihito
× Niimura, Yoshihito× Matsui, Atsushi× Touhara, Kazushige |
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| 著者所属 | ||||||
| 著者所属 | Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Olfactory receptors (ORs) detect odors in the environment, and OR genes constitute the largest multigene family in mammals. Numbers of OR genes vary greatly among species—reflecting the respective species'lifestyles—and this variation is caused by frequent gene gains and losses during evolution. However, whether the extent of gene gains/losses varies among individual gene lineages and what might generate such variation is unknown. To answer these questions, we used a newly developed phylogeny-based method to classify >10,000 intact OR genes from 13 placental mammal species into 781 orthologous gene groups (OGGs); we then compared the OGGs. Interestingly, African elephants had a surprisingly large repertoire (∼2000) of functional OR genes encoded in enlarged gene clusters. Additionally, OR gene lineages that experienced more gene duplication had weaker purifying selection, and Class II OR genes have evolved more dynamically than those in Class I. Some OGGs were highly expanded in a lineage-specific manner, while only three OGGs showed complete one-to-one orthology among the 13 species without any gene gains/losses. These three OGGs also exhibited highly conserved amino acid sequences; therefore, ORs in these OGGs may have physiologically important functions common to every placental mammal. This study provides a basis for inferring OR functions from evolutionary trajectory. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「アフリカゾウはイヌの2倍もの嗅覚受容体遺伝子を持つ」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/ | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "Elephants have twice as many olfactory receptor genes as dogs" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/ | |||||
| 書誌情報 |
Genome research 発行日 2014-07-22 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1088-9051 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1549-5469 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11054029 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1101/gr.169532.113 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (C) 2014 Niimura et al.; Published by Cold Spring Harbor Laboratory Press | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 出版者 | ||||||
| 出版者 | Cold Spring Harbor Laboratory Press | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/ | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/ | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://genome.cshlp.org/content/early/2014/07/16/gr.169532.113.abstract | |||||
