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  1. 116 農学生命科学研究科・農学部
  2. 04 応用生命化学専攻
  3. 1160410 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals

http://hdl.handle.net/2261/56501
http://hdl.handle.net/2261/56501
a23d33ed-4955-427d-b88a-01dba4b9a430
名前 / ファイル ライセンス アクション
GenomeRes.-2014-Niimura-gr.169532.113.pdf GenomeRes.-2014-Niimura-gr.169532.113.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-02-26
タイトル
タイトル Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Niimura, Yoshihito

× Niimura, Yoshihito

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Niimura, Yoshihito

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Matsui, Atsushi

× Matsui, Atsushi

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Matsui, Atsushi

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Touhara, Kazushige

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Touhara, Kazushige

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著者所属
著者所属 Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
著者所属
著者所属 ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo
抄録
内容記述タイプ Abstract
内容記述 Olfactory receptors (ORs) detect odors in the environment, and OR genes constitute the largest multigene family in mammals. Numbers of OR genes vary greatly among species—reflecting the respective species'lifestyles—and this variation is caused by frequent gene gains and losses during evolution. However, whether the extent of gene gains/losses varies among individual gene lineages and what might generate such variation is unknown. To answer these questions, we used a newly developed phylogeny-based method to classify >10,000 intact OR genes from 13 placental mammal species into 781 orthologous gene groups (OGGs); we then compared the OGGs. Interestingly, African elephants had a surprisingly large repertoire (∼2000) of functional OR genes encoded in enlarged gene clusters. Additionally, OR gene lineages that experienced more gene duplication had weaker purifying selection, and Class II OR genes have evolved more dynamically than those in Class I. Some OGGs were highly expanded in a lineage-specific manner, while only three OGGs showed complete one-to-one orthology among the 13 species without any gene gains/losses. These three OGGs also exhibited highly conserved amino acid sequences; therefore, ORs in these OGGs may have physiologically important functions common to every placental mammal. This study provides a basis for inferring OR functions from evolutionary trajectory.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「アフリカゾウはイヌの2倍もの嗅覚受容体遺伝子を持つ」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "Elephants have twice as many olfactory receptor genes as dogs" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/
書誌情報 Genome research

発行日 2014-07-22
ISSN
収録物識別子タイプ ISSN
収録物識別子 1088-9051
ISSN
収録物識別子タイプ ISSN
収録物識別子 1549-5469
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11054029
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1101/gr.169532.113
権利
権利情報 Copyright (C) 2014 Niimura et al.; Published by Cold Spring Harbor Laboratory Press
著者版フラグ
値 publisher
出版者
出版者 Cold Spring Harbor Laboratory Press
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/elephants-have-twice-as-many-olfactory-receptor-genes-as-dogs/
関係URI
識別子タイプ URI
関連識別子 http://genome.cshlp.org/content/early/2014/07/16/gr.169532.113.abstract
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